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Titolo:
Evidence for genetic factors explaining the birth weight-blood pressure relation - Analysis in twins
Autore:
IJzerman, RG; Stehouwer, CDA; Boomsma, DI;
Indirizzi:
Vrije Univ Amsterdam, Acad Hosp, Inst Endocrinol Reprod & Metab, NL-1007 MB Amsterdam, Netherlands Vrije Univ Amsterdam Amsterdam Netherlands NL-1007 MB erdam, Netherlands Vrije Univ Amsterdam, Dept Internal Med, Amsterdam, Netherlands Vrije UnivAmsterdam Amsterdam Netherlands Med, Amsterdam, Netherlands Vrije Univ Amsterdam, Cardiovasc Res Inst, Amsterdam, Netherlands Vrije Univ Amsterdam Amsterdam Netherlands Inst, Amsterdam, Netherlands Vrije Univ Amsterdam, Dept Biol Psychol, Amsterdam, Netherlands Vrije UnivAmsterdam Amsterdam Netherlands chol, Amsterdam, Netherlands
Titolo Testata:
HYPERTENSION
fascicolo: 6, volume: 36, anno: 2000,
pagine: 1008 - 1012
SICI:
0194-911X(200012)36:6<1008:EFGFET>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
MATERNAL NUTRITIONAL-STATUS; IN-UTERO; ADULT HYPERTENSION; DISEASE; ASSOCIATION; OBESITY; HYPOTHESIS; CHILDHOOD; CHILDREN; COHORT;
Keywords:
blood pressure; genetics; twins;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Stehouwer, CDA Vrije Univ Amsterdam, Acad Hosp, Dept Med, De Boelelaan 1117,POB 7057, NL-1007 MB Amsterdam, Netherlands Vrije Univ Amsterdam De Boelelaan 1117,POB 7057 Amsterdam Netherlands NL-1007 MB
Citazione:
R.G. IJzerman et al., "Evidence for genetic factors explaining the birth weight-blood pressure relation - Analysis in twins", HYPERTENSIO, 36(6), 2000, pp. 1008-1012

Abstract

Epidemiological studies have consistently shown an inverse association between birth weight and systolic blood pressure in later life after adjustment for current size. To examine whether this association is explained by intrauterine or genetic factors, we investigated birth weight and blood pressure data in 53 dizygotic and 61 monozygotic adolescent twin pairs. Birth weight was obtained from the mothers. Blood pressure measurements were performed 6 times at rest and during mental stress. The dizgotic but not the monozygotic twins with the lowest birth weight from each pair had a systolic blood pressure measured at rest and during the reaction time experiment that was higher compared with their cotwins with the highest birth weight (dizygotic twins: blood pressure at rest, 119.4+/-9.7 mm Hg versus 117.3+/-8.5 mm Hg, P=0.07, and during a reaction time task, 126.2+/-10.8 versus 123.6+/-9.5, P=0.09; monozygotic twins: blood pressure at rest, 117.4+/-6.4 versus 118.4+/-9.0, P=0.4, and during a reaction time task, 122.9+/-8.4 versus 124.2/-10.8, P=0.2). The differences in blood pressure between the cotwins withthe lowest and the cotwins with the highest birth weight were different indizygotic compared with monozygotic twin pairs (for blood pressure at rest, P=0.05; for blood pressure during reaction time, P=0.03). After adjustment for differences in current weight, intrapair differences in birth weight were negatively and significantly associated with differences in systolic blood pressure at rest and during the reaction time task in dizygotic twins (regression coefficient, -5.7 mm Hg/kg [95% confidence interval, -10.4 to -1.0] and -6.3 [-12.7 to 0], respectively) but not in monozygotic twins (-0.1 [-5.4 to 5.2] and +3.5 [-1.8 to 8.8], respectively). Interaction analysisindicated that the associations were different between dizygotic twins andmonozygotic twins (P=0.1 and P<0.05, respectively). These data suggest that genetic factors may play an important role in the association between birth weight and blood pressure.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 10:22:46