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Titolo:
Synthesis and properties of alpha-thiagra. A substituted 5-(2-thienyl)pyrazolo[4,3-d]pyrimidin-7-one bioisostere of viagra (R)
Autore:
El-Abadelah, MM; Sabri, SS; Khanfar, MA; Voelter, W; Abdel-Jalil, RJ; Maichle-Mossmer, C; Al-Abed, Y;
Indirizzi:
Univ Jordan, Fac Sci, Dept Chem, Amman, Jordan Univ Jordan Amman JordanUniv Jordan, Fac Sci, Dept Chem, Amman, Jordan Univ Tubingen, Inst Phys Chem, Phys Biochem Abt, D-72076 Tubingen, GermanyUniv Tubingen Tubingen Germany D-72076 em Abt, D-72076 Tubingen, Germany Univ Tubingen, Inst Anorgan Chem, D-72076 Tubingen, Germany Univ TubingenTubingen Germany D-72076 n Chem, D-72076 Tubingen, Germany Picower Inst Med Res, Manhasset, NY 11030 USA Picower Inst Med Res Manhasset NY USA 11030 Res, Manhasset, NY 11030 USA
Titolo Testata:
HETEROCYCLES
fascicolo: 12, volume: 53, anno: 2000,
pagine: 2643 -
SICI:
0385-5414(200012)53:12<2643:SAPOAA>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
TYPE-5 CGMP PHOSPHODIESTERASE; CORPUS CAVERNOSUM; NITRIC-OXIDE; SILDENAFIL; PHYSIOLOGY; INHIBITOR; NEUROTRANSMISSION; RELAXATION; ERECTION; RABBIT;
Keywords:
thiophene bioisostere; vasodilation; X-ray structure;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: El-Abadelah, MM Univ Jordan, Fac Sci, Dept Chem, Amman, Jordan Univ Jordan Amman Jordan Sci, Dept Chem, Amman, Jordan
Citazione:
M.M. El-Abadelah et al., "Synthesis and properties of alpha-thiagra. A substituted 5-(2-thienyl)pyrazolo[4,3-d]pyrimidin-7-one bioisostere of viagra (R)", HETEROCYCLE, 53(12), 2000, pp. 2643

Abstract

For structure-activity manipulations, the compound alpha -thiagra (3), a thiophene bioisostere of viagra(R), has been prepared and its X-Ray structure determined. The crystallographic data show that the thiophene and pyrazolo[4,3-d]pyrimidone hetero-ring systems are nearly coplanar by virtue of an adequate intramolecular hydrogen-bond between the pyrimidone NH and the oxygen lone pair of the 3'-ethoxy group.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/07/20 alle ore 08:46:42