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Titolo:
Neoplasms in neurofibromatosis 1 are related to gender but not to family history of cancer
Autore:
Airewele, GE; Sigurdson, AJ; Wiley, KJ; Frieden, BE; Caldarera, LW; Riccardi, VM; Lewis, RA; Chintagumpala, MM; Ater, JL; Plon, SE; Bondy, ML;
Indirizzi:
Univ Texas, MD Anderson Canc Ctr, Dept Epidemiol, Houston, TX 77030 USA Univ Texas Houston TX USA 77030 tr, Dept Epidemiol, Houston, TX 77030 USA Baylor Coll Med, Texas Childrens Canc Ctr, Houston, TX USA Baylor Coll Med Houston TX USA Texas Childrens Canc Ctr, Houston, TX USA Baylor Coll Med, Dept Pediat, Houston, TX 77030 USA Baylor Coll Med Houston TX USA 77030 , Dept Pediat, Houston, TX 77030 USA Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA Baylor CollMed Houston TX USA 77030 & Human Genet, Houston, TX 77030 USA Univ Texas, MD Anderson Canc Ctr, Dept Pediat Hematol & Oncol, Houston, TX77030 USA Univ Texas Houston TX USA 77030 iat Hematol & Oncol, Houston, TX77030 USA Baylor Coll Med, Dept Ophthalmol, Houston, TX USA Baylor Coll Med HoustonTX USA oll Med, Dept Ophthalmol, Houston, TX USA Baylor Coll Med, Dept Med, Houston, TX USA Baylor Coll Med Houston TX USA aylor Coll Med, Dept Med, Houston, TX USA Amer Med Consumers, La Crescenta, CA USA Amer Med Consumers La Crescenta CA USA d Consumers, La Crescenta, CA USA
Titolo Testata:
GENETIC EPIDEMIOLOGY
fascicolo: 1, volume: 20, anno: 2001,
pagine: 75 - 86
SICI:
0741-0395(200101)20:1<75:NIN1AR>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
VONRECKLINGHAUSEN NEUROFIBROMATOSIS; CHILDHOOD; TYPE-1; ANTICIPATION; EXPRESSION; ACCURACY; MENINGIOMAS; MUTATION; SEVERITY; TUMORS;
Keywords:
family studies; cohort studies; gender; risk;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Bondy, ML Univ Texas, MD Anderson Canc Ctr, Dept Epidemiol, 1515 Holcombe Blvd,Box 189, Houston, TX 77030 USA Univ Texas 1515 Holcombe Blvd,Box 189 Houston TX USA 77030 0 USA
Citazione:
G.E. Airewele et al., "Neoplasms in neurofibromatosis 1 are related to gender but not to family history of cancer", GENET EPID, 20(1), 2001, pp. 75-86

Abstract

The risk of malignancies among persons with neurofibromatosis 1 (NF1) is higher than in the general population, but the excess risk has not been precisely estimated. The effects of gender and inheritance pattern on cancer risk are unclear. Therefore, we conducted a historical cohort study to determine cancer risk factors by contacting 138 Caucasian NF1 patients originallyseen at Baylor College of Medicine (BCM) in Houston between 1978 and 1984. A total of 304 patients of all ethnic groups were evaluated at BCM during this period. We successfully located 173 patients, 138 of who were Caucasian. We computed standardized incidence ratios (SIRs) with the age-, gender-,and time period-specific rates from the Connecticut Tumor Registry for 2,094 person-years of observation (median follow-up = 16 years). Eleven incident tumors were reported. Females were at much higher risk of cancer than males (SIR = 5.6, 95% confidence interval (CI) 2.7-10.3 and SIR = 0.6; 95% CI, 0.0-3.0, respectively). We found no elevated cancer risk in unaffected first-degree relatives, regardless of whether the proband had cancer or not (SLR = 1.1 95% CI, 0.6-1.8 and SIR = 1.0, 95% CI, 0.6-1.5, respectively). Our results suggest that malignancy in the proband is not the result of a modifying gene that has a significant impact on general cancer risk. Genet. Epidemiol. 20:75-86, 2001. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/05/20 alle ore 14:42:06