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Titolo:
Altered endothelium-dependent responsiveness in the aortas and renal arteries of Otsuka Long-Evans Tokushima Fatty (OLETF) rats, a model of non-insulin-dependent diabetes mellitus
Autore:
Kagota, S; Yamaguchi, Y; Nakamura, K; Kunitomo, M;
Indirizzi:
Mukogawa Womens Univ, Fac Pharmaceut Sci, Dept Pharmacol, Nishinomiya, Hyogo 6638179, Japan Mukogawa Womens Univ Nishinomiya Hyogo Japan 6638179 Hyogo 6638179, Japan
Titolo Testata:
GENERAL PHARMACOLOGY-THE VASCULAR SYSTEM
fascicolo: 3, volume: 34, anno: 2000,
pagine: 201 - 209
SICI:
0306-3623(200003)34:3<201:AERITA>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITRIC-OXIDE SYNTHASE; LOW-DENSITY-LIPOPROTEIN; INDEPENDENT VASODILATION; SMOOTH-MUSCLE; RELAXATION; PEROXYNITRITE; CONTRACTION; RESISTANCE; CELLS; HYPERCHOLESTEROLEMIA;
Keywords:
aorta; renal artery; endothelium-dependent response; Otsuka Long-Evans Tokushima Fatty (OLETF) rat; non-insulin-dependent diabetes mellitus; nitric oxide;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Kagota, S Mukogawa Womens Univ, Fac Pharmaceut Sci, Dept Pharmacol, 11-68 Koshien Kyuban Cho, Nishinomiya, Hyogo 6638179, Japan Mukogawa Womens Univ 11-68 Koshien Kyuban Cho Nishinomiya Hyogo Japan 6638179
Citazione:
S. Kagota et al., "Altered endothelium-dependent responsiveness in the aortas and renal arteries of Otsuka Long-Evans Tokushima Fatty (OLETF) rats, a model of non-insulin-dependent diabetes mellitus", GEN PH-VASC, 34(3), 2000, pp. 201-209

Abstract

We examined endothelium-dependent relaxation in the aortas and renal arteries of Otsuka Long-Evans Tokushima Fatty (OLETF) rats, a model of non-insulin-dependent diabetes mellitus, in comparison with non-diabetic Long-Evans Tokushima Otsuka rats as controls. Acetylcholine-induced relaxation in botharteries was attenuated, and the attenuation was restored to the control level by indomethacin. The relaxation was inhibited completely in the aortas, but only partially in renal arteries by N-G-nitro-L-arginine methyl ester, and the degree of the latter inhibition was greater in OLETF rats than inthe controls. The relaxation was inhibited by aminoguanidine in both arteries of OLETF rats but not in the controls. Serum NO2 plus NO3 levels significantly increased in OLETF rats. These results suggest that impairment of relaxation in OLETF rat arteries is due to increased release of contractile factors but not decreased release of nitric oxide. (C) 2000 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 00:00:47