Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Contribution of sodium channel and sodium/hydrogen exchanger to sodium accumulation in the ischemic myocardium
Autore:
Tanonaka, K; Takasaki, A; Kajiwara, H; Takeo, S;
Indirizzi:
Tokyo Univ Pharm & Life Sci, Dept Pharmacol, Hachioji, Tokyo 1920392, Japan Tokyo Univ Pharm & Life Sci Hachioji Tokyo Japan 1920392 o 1920392, Japan
Titolo Testata:
GENERAL PHARMACOLOGY-THE VASCULAR SYSTEM
fascicolo: 3, volume: 34, anno: 2000,
pagine: 167 - 174
SICI:
0306-3623(200003)34:3<167:COSCAS>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
NA+-H+ EXCHANGE; POSTISCHEMIC VENTRICULAR RECOVERY; REPERFUSED RAT HEARTS; CONTRACTILE FAILURE; PERFUSED HEARTS; POSSIBLE INVOLVEMENT; AMILORIDE; CALCIUM; INJURY; INHIBITORS;
Keywords:
dimethylamirolide; ischemia; sodium accumulation; sodium channel; sodium/hydrogen exchanger; tetrodotoxin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Takeo, S Tokyo Univ Pharm & Life Sci, Dept Pharmacol, 1432-1 Horinouchi, Hachioji, Tokyo 1920392, Japan Tokyo Univ Pharm & Life Sci 1432-1 HorinouchiHachioji Tokyo Japan 1920392
Citazione:
K. Tanonaka et al., "Contribution of sodium channel and sodium/hydrogen exchanger to sodium accumulation in the ischemic myocardium", GEN PH-VASC, 34(3), 2000, pp. 167-174

Abstract

Contribution of sodium channels and sodium/hydrogen exchangers (NHEs) to sodium accumulation during ischemia in the ischemic/reperfused heart was examined. Ischemia increased the myocardial sodium. Reperfusion elicited a further increase in the myocardial sodium, which was associated with little recovery of the left ventricular developed pressure (LVDP) of the perfused heart. Treatment with tetrodotoxin or dimethylamirolide (DMA) dose-dependently attenuated the ischemia- and reperfusion-induced increase in myocardial sodium and enhanced the post-ischemic recovery of the LVDP. There was an inverse relationship between the increase in myocardial sodium during ischemiaand the post-ischemic recovery of the LVDP. The myocardial sodium accumulation during ischemia is mainly attributed to sodium influx through sodium channels and NHEs. (C) 2000 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 01:00:23