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Titolo:
Genetic analysis of cardiovascular risk factor clustering in spontaneous hypertension
Autore:
Pravenec, M; Zidek, V; Landa, V; Kostka, V; Musilova, A; Kazdova, L; Fucikova, A; Krenova, D; Bila, V; Kren, V;
Indirizzi:
Acad Sci Czech Republ, Inst Physiol, Prague 14220 4, Czech Republic Acad Sci Czech Republ Prague Czech Republic 14220 4 20 4, Czech Republic Charles Univ, Inst Biol & Med Genet, Fac Med 1, Prague, Czech Republic Charles Univ Prague Czech Republic t, Fac Med 1, Prague, Czech Republic Acad Sci Czech Republ, Inst Mol Genet, Prague, Czech Republic Acad Sci Czech Republ Prague Czech Republic net, Prague, Czech Republic Inst Clin & Expt Med, Prague, Czech Republic Inst Clin & Expt Med PragueCzech Republic Med, Prague, Czech Republic Czech Agr Univ, Prague, Czech Republic Czech Agr Univ Prague Czech Republic h Agr Univ, Prague, Czech Republic
Titolo Testata:
FOLIA BIOLOGICA
fascicolo: 6, volume: 46, anno: 2000,
pagine: 233 - 240
SICI:
0015-5500(2000)46:6<233:GAOCRF>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
QUANTITATIVE TRAIT LOCI; RECOMBINANT INBRED STRAINS; INSULIN-RESISTANCE; BLOOD-PRESSURE; FATTY-ACID; LINKAGE MAP; RATS; GLUCOSE; METABOLISM; CD36;
Keywords:
insulin resistance; dyslipidemia; hypertension; SHR-4 congenic strain; Cd36; Cd36-transgenic rats;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Pravenec, M Acad Sci Czech Republ, Inst Physiol, Videnska 1083, Prague 14220 4, Czech Republic Acad Sci Czech Republ Videnska 1083 Prague Czech Republic 14220 4
Citazione:
M. Pravenec et al., "Genetic analysis of cardiovascular risk factor clustering in spontaneous hypertension", FOL BIOL, 46(6), 2000, pp. 233-240

Abstract

The SHR is the most widely studied animal model of hypertension, In this strain, as in many humans with essential hypertension, increased blood pressure has been reported to cluster with other risk factors for cardiovasculardisease, including insulin resistance and dyslipidemia. However, the genetic mechanisms that mediate this clustering of risk factors for cardiovascular disease or the hypertension "metabolic syndrome" remain poorly understood. In the current studies, we have demonstrated (1) that a gene or genes responsible for a whole spectrum of cardiovascular risk factors mapped to a limited segment of the centromeric region of rat chromosome 4, (2) that a spontaneous deletion in the gene for Cd36 that encodes a fatty acid transporter and is located directly at the peak of QTL linkages on chromosome 4 has been indirectly linked to the transmission of insulin resistance, defectivefatty acid metabolism, and increased blood pressure, and (3) based on complementation analysis in two transgenic lines expressing wild-type Cd36 on the genetic background of the STIR strain harboring the deletion variant of Cd36, we have established that defective Cd36 can be a determinant of disordered fatty acid metabolism, glucose intolerance, and insulin resistance inspontaneous hypertension.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 23:51:26