Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Ovariectomy and 17 beta-estradiol modulate the levels of Alzheimer's amyloid beta peptides in brain
Autore:
Petanceska, SS; Nagy, V; Frail, D; Gandy, S;
Indirizzi:
Nathan S Kline Inst Psychiat Res, Orangeburg, NY 10962 USA Nathan S Kline Inst Psychiat Res Orangeburg NY USA 10962 rg, NY 10962 USA NYU, Med Ctr, New York, NY 10016 USA NYU New York NY USA 10016NYU, Med Ctr, New York, NY 10016 USA Wyeth Ayerst Res, Womens Hlth Res Inst, Radnor, PA 19087 USA Wyeth Ayerst Res Radnor PA USA 19087 Hlth Res Inst, Radnor, PA 19087 USA
Titolo Testata:
EXPERIMENTAL GERONTOLOGY
fascicolo: 9-10, volume: 35, anno: 2000,
pagine: 1317 - 1325
SICI:
0531-5565(200012)35:9-10<1317:OA1BMT>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
PRECURSOR PROTEIN; NEUROBLASTOMA-CELLS; SECRETASE CLEAVAGE; ESTRADIOL; ESTROGEN;
Keywords:
amyloid beta; estrogen replacement therapy; 17 beta-estradiol; guinea pigs; animal model;
Tipo documento:
Reprint
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Gandy, S Nathan S Kline Inst Psychiat Res, 140 Old Orangeburg Rd, Orangeburg, NY 10962 USA Nathan S Kline Inst Psychiat Res 140 Old Orangeburg Rd Orangeburg NY USA 10962
Citazione:
S.S. Petanceska et al., "Ovariectomy and 17 beta-estradiol modulate the levels of Alzheimer's amyloid beta peptides in brain", EXP GERONT, 35(9-10), 2000, pp. 1317-1325

Abstract

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by accumulation of aggregated forms of the 40- and 42-amino acid A beta peptides (A beta 40 and A beta 42). Estrogen replacement therapy (ERT) in postmenopausal women is associated with decreased risk for AD and/or delay in disease onset. The mechanism by which estrogen exerts this neuroprotective effect is elusive. 17 beta -estradiol (E2) was shown to reduce the release of Abeta peptides by primary neuronal cultures of murine and human origin. To test whether estrogen can modulate the metabolism of A beta peptides in vivo, four experimental sets of guinea pigs were used: intact animals, ovariectomized animals, and ovariectomized animals that received E2 at two different doses. Ovariectomy was associated with a 1.5-fold average increase in total brain A beta levels as compared to intact controls. E2 treatment significantly reversed the ovariectomy-induced increase in brain A beta levels. The high-dose E2 treatment did not lead to further decrease in brain A beta beyond the one observed with the low-dose E2 treatment. Our results infer that cessation of ovarian estrogen production in postmenopausal women might facilitate A beta deposition by increasing the local concentrations of A beta 40 and A beta 42 peptides in brain and suggest that modulation of AP metabolism may be one of the ways by which ERT prevents and/or delays the onset of AD in postmenopausal women. (C) 2000 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 05:45:06