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Titolo:
Is there a correlation between organochlorine compounds and undescended testes?
Autore:
Hosie, S; Loff, S; Witt, K; Niessen, K; Waag, KL;
Indirizzi:
Univ Heidelberg, Mannheim Univ Hosp, Dept Paediat Surg, D-68167 Mannheim, Germany Univ Heidelberg Mannheim Germany D-68167 Surg, D-68167 Mannheim, Germany Mannheim Univ Hosp, Dept Paediat, Mannheim, Germany Mannheim Univ Hosp Mannheim Germany sp, Dept Paediat, Mannheim, Germany
Titolo Testata:
EUROPEAN JOURNAL OF PEDIATRIC SURGERY
fascicolo: 5, volume: 10, anno: 2000,
pagine: 304 - 309
SICI:
0939-7248(200010)10:5<304:ITACBO>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
REPRODUCTIVE-TRACT; TOXIC-SUBSTANCES; PESTICIDES; DIETHYLSTILBESTROL; POLLUTANTS; ESTROGENS; CHEMICALS;
Keywords:
pesticides; xenooestrogens; environmental pollutants; testicular descent; cryptorchidism; undescended testes;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Hosie, S Univ Heidelberg, Mannheim Univ Hosp, Dept Paediat Surg, Theodor Kutzer Ufer 1-3, D-68167 Mannheim, Germany Univ Heidelberg Theodor Kutzer Ufer 1-3 Mannheim Germany D-68167
Citazione:
S. Hosie et al., "Is there a correlation between organochlorine compounds and undescended testes?", EUR J PED S, 10(5), 2000, pp. 304-309

Abstract

Some pesticides and synthetic chemicals are known to act as hormonal modulators, often possessing oestrogenic activity (xenooestrogens). They are persistent and accumulate in fatty tissue. Aim of our study is to address the question, whether a selection of such compounds is to be found in the fattytissue of children undergoing surgical procedures and whether there are differences in values obtained from patients with or without undescended testes. Fat samples of 48 patients, 18 of whom had undescended testes, were examined by high-resolution gas chromatography and mass spectrometry for DDT and metabolites, polychlorinated biphenyls (PCB), toxaphenes, hexachlorocyclohexane (HCH), chlorinated cyclodienes and chlorinated benzenes. We were able to find accumulation of all substances in every patient. Statistical analysis revealed a highly significant difference between patients from the control group and those from the undescended testes group for two compounds, namely heptachloroepoxide (HCE) and hexachlorobenzene (HCB), increased values being found in the patients with undescended testes. Since the aetiologyof this entity is unknown in most of the cases, prenatal exposure to exogenous oestrogens is an attractive and plausible hypothesis. In order to confirm this, some questions will have to be answered in further studies: effect of exposure to xenooestrogens during a specific period of development, probable role of other substances with proven or suspected hormonal activity,potential synergism of such compounds and differences in individual susceptibility.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 20:07:09