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Titolo:
Life-style factors and risk for abdominal aortic aneurysm in a cohort, of Finnish male smokers
Autore:
Tornwall, ME; Virtamo, J; Haukka, JK; Albanes, D; Huttunen, JK;
Indirizzi:
KTL Natl Publ Hlth Inst, Dept Nutr, ATBC Study, Helsinki 00300, Finland KTL Natl Publ Hlth Inst Helsinki Finland 00300 , Helsinki 00300, Finland NCI, Bethesda, MD 20892 USA NCI Bethesda MD USA 20892NCI, Bethesda, MD 20892 USA
Titolo Testata:
EPIDEMIOLOGY
fascicolo: 1, volume: 12, anno: 2001,
pagine: 94 - 100
SICI:
1044-3983(200101)12:1<94:LFARFA>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY HEART-DISEASE; WESTERN-AUSTRALIA; CHOLESTEROL; POPULATION; ATHEROSCLEROSIS; EPIDEMIOLOGY; DEATH; DIET; MEN;
Keywords:
abdominal aortic aneurysm; cohort study; smoking; blood pressure; serum cholesterol; HDL cholesterol; diet;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Tornwall, ME KTL Natl Publ Hlth Inst, Dept Nutr, ATBC Study, Mannerheiminie 166, Helsinki 00300, Finland KTL Natl Publ Hlth Inst Mannerheiminie 166 Helsinki Finland 00300
Citazione:
M.E. Tornwall et al., "Life-style factors and risk for abdominal aortic aneurysm in a cohort, of Finnish male smokers", EPIDEMIOLOG, 12(1), 2001, pp. 94-100

Abstract

Prospective studies evaluating risk factors for abdominal aortic aneurysm are few. We studied the association of life-style factors with risk for abdominal aortic aneurysm among 29,133 male smokers 50-69 years of age, participants in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study. During a mean follow-up of 5.8 years, 181 were diagnosed with ruptured abdominal aortic aneurysm or nonruptured abdominal aortic aneurysm plus aneurysmectomy. Risk for abdominal aortic aneurysm was positively associated with age [relative risk (RR) = 4.56, 95% confidence interval (CI) = 2.42-8.61 for >65 vs less than or equal to 55 years], smoking years (RR = 2.25, 95% CI = 1.33-3.81 for >40 vs less than or equal to 32 years), systolic blood pressure(RR = 1.92, 95% CI = 1.13-3.25 for >160 vs less than or equal to 130 mmHg), diastolic blood pressure (RR = 1.80, 95% CI = 1.05-3.08 for >100 vs less than or equal to 85 mmHg), and serum total cholesterol (RR = 1.85, 95% CI =1.09-3.12 for >6.5 vs less than or equal to5.0 mmol/liter). High-density lipoprotein cholesterol showed a strong inverse association with risk for aortic aneurysm (RR = 0.16, 95% CI = 0.08-0.32 for >1.5 vs less than or equalto0.9 mmol/liter). High energy intake was associated with lower risk for aortic aneurysm (RR = 0.59, 95% CI = 0.38-0.94 for the highest quartile vs the lowest), whereas no associations with nutrients were evident. We conclude that classical risk factors fur atherosclerotic diseases seem to be important in pathogenesis of large abdominal aortic aneurysms.

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Documento generato il 13/07/20 alle ore 20:19:12