Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Embryotoxicity of the alkylphenol degradation product 4-nonylphenol to thecrustacean Daphnia magna
Autore:
LeBlanc, GA; Mu, XY; Rider, CV;
Indirizzi:
N Carolina State Univ, Dept Toxicol, Raleigh, NC 27695 USA N Carolina State Univ Raleigh NC USA 27695 Toxicol, Raleigh, NC 27695 USA
Titolo Testata:
ENVIRONMENTAL HEALTH PERSPECTIVES
fascicolo: 12, volume: 108, anno: 2000,
pagine: 1133 - 1138
SICI:
0091-6765(200012)108:12<1133:EOTADP>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
TESTOSTERONE; NONYLPHENOL;
Keywords:
androgens; crustacean; Daphnia magna; development; embryo; invertebrate; 4-nonylphenol; steroids; testosterone; toxicity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: LeBlanc, GA N Carolina State Univ, Dept Toxicol, Box 7633, Raleigh, NC 27695 USA N Carolina State Univ Box 7633 Raleigh NC USA 27695 27695 USA
Citazione:
G.A. LeBlanc et al., "Embryotoxicity of the alkylphenol degradation product 4-nonylphenol to thecrustacean Daphnia magna", ENVIR H PER, 108(12), 2000, pp. 1133-1138

Abstract

Laboratory studies have suggested that some alkylphenols and pesticides elicit developmental toxicity to crustaceans. The purpose of the present study was to evaluate the possibility that the alkylphenol degradation product 4-nonylphenol is embryotoxic to the crustacean Daphnia magna through its known ability to interfere with the metabolic elimination of testosterone. Direct exposure of maternal daphnids to testosterone caused developmental abnormalities in neonates that consisted of partial arrest of early embryonic development and abnormalities in shell spine and first antennae development. Exposure of maternal daphnids to concentrations of 4-nonylphenol also produced developmental abnormalities though the profile of abnormalities was distinct from that observed throughout the testosterone concentration-response curve. Thus, 4-nonylphenol is a developmental toxicant in daphnids, but its toxicity is not consistent with that elicited by elevated testosterone accumulation. Further experiments demonstrated that testosterone was directly toxic to developing embryos, and the maternal organism can serve as the vector for this toxicity. In contrast, neither direct embryo exposure nor early maternal exposure to 4-nonylphenol elicited embryotoxicity consistent with that observed during continuous maternal and gestational exposure. Thus, 4-nonylphenol is not directly embryotoxic at these exposure levels, but rather toxicity is mediated by maternal influences during gestation. The threshold concentration for the occurrence of developmental abnormalities (similar to 44 mug/L) indicates that typical environmental concentrations of 4-nonylphenol pose no imminent hazard with respect to developmental toxicity. However, these effects do occur at sufficiently low levels to warrant evaluation of the relative susceptibility of other crustacean species to this previously uncharacterized mode of toxicity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 06:16:19