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Titolo:
Fetal hypothalamic-pituitary adrenal (HPA) development and activation as adeterminant of the timing of birth, and of postnatal disease
Autore:
Challis, J; Sloboda, D; Matthews, S; Holloway, A; Alfaidy, N; Howe, D; Fraser, M; Newnham, J;
Indirizzi:
Univ Toronto, Fac Med, Dept Physiol, Toronto, ON M5S 1A8, Canada Univ Toronto Toronto ON Canada M5S 1A8 ysiol, Toronto, ON M5S 1A8, Canada Univ Western Australia, Dept Obstet Gynecol, MRC, Grp Fetal & Neonatal Hlth & Dev, Perth, WA 6009, Australia Univ Western Australia Perth WA Australia 6009 Perth, WA 6009, Australia
Titolo Testata:
ENDOCRINE RESEARCH
fascicolo: 4, volume: 26, anno: 2000,
pagine: 489 - 504
SICI:
0743-5800(2000)26:4<489:FHA(DA>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
MESSENGER-RIBONUCLEIC-ACID; GENE-EXPRESSION; HUMAN PLACENTA; PROLONGED HYPOXEMIA; OVINE FETUS; SHEEP; CORTISOL; GLAND; PROOPIOMELANOCORTIN; CORTICOTROPIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Challis, J Univ Toronto, Fac Med, Dept Physiol, 1 Kings Coll Circle, Toronto, ON M5S 1A8, Canada Univ Toronto 1 Kings Coll Circle Toronto ON Canada M5S 1A8 nada
Citazione:
J. Challis et al., "Fetal hypothalamic-pituitary adrenal (HPA) development and activation as adeterminant of the timing of birth, and of postnatal disease", ENDOCRINE R, 26(4), 2000, pp. 489-504

Abstract

Birth in most animal species is triggered by the fetus through activation of the fetal hypothalamic-pituitary-adrenal (HPA) axis. Preterm birth, may be associated with precocious activation of fetal HPA function, reflecting the fetal response to an adverse intrauterine environment. There is a progressive and concurrent increase of ACTH(1-39) and cortisol (F) in the circulation of fetal sheep during the last 15-20 days of pregnancy (term, day 145-150) associated with increased expression of hypothalamicCRH pituitary POMC and adrenal ACTH receptor and steroidogenic enzymes, particularly P450 C17. Similar changes occur with fetal hypoxemia. Negative feedback is ameliorated by decreased pituitary and hypothalamic glucocorticoid receptor, increased CBG, and altered fetal pituitary 11 beta -hydroxysteroid dehydrogenase type 1. Repeated fetal hypoxemia, diminishes the fetal-pituitary ACTH response, but increases fetal adrenal responsiveness. Fetusesexposed to maternal glucocorticoid in late gestation are growth restrictedwith altered postnatal HPA responsiveness and glycemic responses that reproduce the insulin resistance of type 2 diabetes. We conclude that the levelof fetal HPA activity is crucial not only for determining gestation length, but also predicts pathophysiologic adjustment in later life.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/04/20 alle ore 22:27:20