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Titolo:
Brain plasmin enhances APP alpha-cleavage and A beta degradation and is reduced in Alzheimer's disease brains
Autore:
Ledesma, MD; Da Silva, JS; Crassaerts, K; Delacourte, A; De Strooper, B; Dotti, CG;
Indirizzi:
European Mol Biol Lab, Cell Biol & Biophys Program, Heidelberg, Germany European Mol Biol Lab Heidelberg Germany s Program, Heidelberg, Germany Flanders Interuniv, Inst Biotechnol, Louvain, Belgium Flanders Interuniv Louvain Belgium v, Inst Biotechnol, Louvain, Belgium Katholieke Univ Leuven, Ctr Human Genet, Louvain, Belgium Katholieke Univ Leuven Louvain Belgium tr Human Genet, Louvain, Belgium INSERM, U422, F-59045 Lille, France INSERM Lille France F-59045INSERM, U422, F-59045 Lille, France Univ Turin, AO San Luigi Gonzaga, Cavalieri Ottolenghi Sci Inst, I-10043 Orbassano, TO, Italy Univ Turin Orbassano TO Italy I-10043 Inst, I-10043 Orbassano, TO, Italy
Titolo Testata:
EMBO REPORTS
fascicolo: 6, volume: 1, anno: 2000,
pagine: 530 - 535
SICI:
1469-221X(200012)1:6<530:BPEAAA>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMYLOID PRECURSOR PROTEIN; HIPPOCAMPAL-NEURONS; SECRETASE CLEAVAGE; NERVOUS-SYSTEM; CELL BIOLOGY; ACTIVATOR; METALLOPROTEASE; EXPRESSION; FRAGMENTS; SURFACE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Dotti, CG European Mol Biol Lab, Cell Biol & Biophys Program, Heidelberg, Germany European Mol Biol Lab Heidelberg Germany Heidelberg, Germany
Citazione:
M.D. Ledesma et al., "Brain plasmin enhances APP alpha-cleavage and A beta degradation and is reduced in Alzheimer's disease brains", EMBO REP, 1(6), 2000, pp. 530-535

Abstract

The proteolytic processing of amyloid precursor protein (APP) has been linked to sphingolipid-cholesterol microdomains (rafts). However, the raft proteases that may be involved in APP cleavage have not yet been identified. In this work we present evidence that the protease plasmin is restricted to rafts of cultured hippocampal neurons. We also show that plasmin increases the processing of human APP preferentially at the alpha -cleavage site, andefficiently degrades secreted amyloidogenic and non-amyloidogenic APP fragments. These results suggest that brain plasmin plays a preventive role in APP amyloidogenesis. Consistently, we show that brain tissue from Alzheimer's disease patients contains reduced levels of plasmin, implying that plasmin downregulation may cause amyloid plaque deposition accompanying sporadicAlzheimer's disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 10:55:51