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Titolo:
The murine SNF5/INI1 chromatin remodeling factor is essential for embryonic development and tumor suppression
Autore:
Klochendler-Yeivin, A; Fiette, L; Barra, J; Muchardt, C; Babinet, C; Yaniv, M;
Indirizzi:
Inst Pasteur, CNRS, URA 1644, Unite Virus Oncogenes, F-75724 Paris 15, France Inst Pasteur Paris France 15 e Virus Oncogenes, F-75724 Paris 15, France Inst Pasteur, CNRS, URA 1960, Unite Histopathol, F-75724 Paris, France Inst Pasteur Paris France F-75724 ite Histopathol, F-75724 Paris, France Inst Pasteur, CNRS, URA 1960, Unite Biol Dev, F-75724 Paris 15, France Inst Pasteur Paris France 15 0, Unite Biol Dev, F-75724 Paris 15, France
Titolo Testata:
EMBO REPORTS
fascicolo: 6, volume: 1, anno: 2000,
pagine: 500 - 506
SICI:
1469-221X(200012)1:6<500:TMSCRF>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
SWI-SNF COMPLEX; TRANSCRIPTIONAL ACTIVATORS; RETINOBLASTOMA; HSNF5/INI1; MUTATIONS; FAMILY; CANCER; EXPRESSION; COOPERATE; PROTEIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Yaniv, M Inst Pasteur, CNRS, URA 1644, Unite Virus Oncogenes, 25 Rue Dr Roux, F-75724 Paris 15, France Inst Pasteur 25 Rue Dr Roux Paris France 15 724 Paris 15, France
Citazione:
A. Klochendler-Yeivin et al., "The murine SNF5/INI1 chromatin remodeling factor is essential for embryonic development and tumor suppression", EMBO REP, 1(6), 2000, pp. 500-506

Abstract

The assembly of eukaryotic DNA into nucleosomes and derived higher order structures constitutes a barrier for transcription, replication and repair. A number of chromatin remodeling complexes, as well as histone acetylation,were shown to facilitate gene activation. To investigate the function of two closely related mammalian SWI/SNF complexes in vivo, we inactivated the murine SNF5/INI1 gene, a common subunit of these two complexes. Mice lacking SNF5 protein stop developing at the peri-implantation stage, showing thatthe SWI/SNF complex is essential for early development and viability of early embryonic cells. Furthermore, heterozygous mice develop nervous system and soft tissue sarcomas. In these tumors the wild-type allele was lost, providing further evidence that SNF5 functions as a tumor suppressor gene in certain cell types.

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Documento generato il 23/01/21 alle ore 03:28:23