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Titolo:
Type 2 diabetes and the metabolic syndrome in Japanese Americans
Autore:
Fujimoto, WY; Bergstrom, RW; Boyko, EJ; Chen, KW; Kahn, SE; Leonetti, DL; McNeely, MJ; Newell, LL; Shofer, JB; Wahl, PW;
Indirizzi:
Univ Washington, Div Metab Endocrinol & Nutr, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 crinol & Nutr, Seattle, WA 98195 USA
Titolo Testata:
DIABETES RESEARCH AND CLINICAL PRACTICE
, volume: 50, anno: 2000, supplemento:, 2
pagine: S73 - S76
SICI:
0168-8227(200010)50:<S73:T2DATM>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY HEART-DISEASE; BODY-FAT DISTRIBUTION; 5-YEAR FOLLOW-UP; GLUCOSE-INTOLERANCE; VISCERAL ADIPOSITY; INSULIN-SECRETION; C-PEPTIDE; MEN; ASSOCIATION; NIDDM;
Keywords:
type 2 diabetes; central adiposity; insulin resistance;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Fujimoto, WY Univ Washington, Div Metab Endocrinol & Nutr, Room BB545,HlthSci Bldg,1959 NE Pacific St,POB 3, Seattle, WA 98195 USA Univ Washington Room BB545,Hlth Sci Bldg,1959 NE Pacific St,POB 3 Seattle WA USA 98195
Citazione:
W.Y. Fujimoto et al., "Type 2 diabetes and the metabolic syndrome in Japanese Americans", DIABET RE C, 50, 2000, pp. S73-S76

Abstract

Japanese Americans have experienced a higher prevalence of type 2 diabetesthan in Japan. Research conducted in Seattle suggests that lifestyle factors associated with 'westernization' play a role in bringing out this susceptibility to diabetes. These lifestyle factors include consumption of a diethigher in saturated fat and reduced physical activity. A consequence of this is the development of central (visceral) adiposity, insulin resistance, and other features associated with this insulin resistance metabolic syndrome, such as dyslipidemia thigh triglycerides, low HDL-cholesterol, and small and dense LDL particles), hypertension, and coronary heart disease. We have postulated that the superimposition of insulin resistance upon a geneticbackground of reduced beta -cell reserve results in hyperglycemia and diabetes among Japanese Americans. This article reviews evidence that support this view. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 09:46:56