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Titolo:
Relationship between interleukin-6 plasma concentration in patients with sepsis, monocyte phenotype, monocyte phagocytic properties, and cytokine production
Autore:
Spittler, A; Razenberger, M; Kupper, H; Kaul, M; Hackl, W; Boltz-Nitulescu, G; Fugger, RF; Roth, E;
Indirizzi:
Univ Vienna, Surg Res Labs, A-1090 Vienna, Austria Univ Vienna Vienna Austria A-1090 Surg Res Labs, A-1090 Vienna, Austria Univ Vienna, Inst Gen & Expt Pathol, Vienna, Austria Univ Vienna Vienna Austria nna, Inst Gen & Expt Pathol, Vienna, Austria Kaiser Franz Josef Hosp, Surg ICU, Vienna, Austria Kaiser Franz Josef Hosp Vienna Austria Hosp, Surg ICU, Vienna, Austria Knoll AG, D-6700 Ludwigshafen, Germany Knoll AG Ludwigshafen Germany D-6700 ll AG, D-6700 Ludwigshafen, Germany
Titolo Testata:
CLINICAL INFECTIOUS DISEASES
fascicolo: 6, volume: 31, anno: 2000,
pagine: 1338 - 1342
SICI:
1058-4838(200012)31:6<1338:RBIPCI>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; DR ANTIGEN EXPRESSION; SEPTIC SHOCK; 1-ALPHA,25-DIHYDROXYVITAMIN D-3; INTERFERON-GAMMA; FACTOR-ALPHA; ENDOTOXIN; SURGERY; SERUM; TNF;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Spittler, A Univ Vienna, Surg Res Labs, AKH-8H-G9-13,Waehringer Guertel 18-20, A-1090 Vienna, Austria Univ Vienna AKH-8H-G9-13,Waehringer Guertel 18-20 Vienna Austria A-1090
Citazione:
A. Spittler et al., "Relationship between interleukin-6 plasma concentration in patients with sepsis, monocyte phenotype, monocyte phagocytic properties, and cytokine production", CLIN INF D, 31(6), 2000, pp. 1338-1342

Abstract

Monocyte phenotype, their phagocytic capacity as well as the cytokine production from 10 patients with sepsis with low interleukin-6 (IL-6) serum concentrations (<1000 pg/mL) and 8 patients with sepsis with high IL-6 (<greater than or equal to>1000 pg/mL) plasma concentrations were investigated within 24 hours of fulfilling the criteria for sepsis. Monocytes from patientswith high IL-6 levels had higher levels of human leukocyte antigen (HLA)-DR, HLA-ABC, CD64, and CD71, and the production of tumor necrosis factor-alpha (TNF-alpha) and IL-8, as well as the capacity of monocytes to phagocytose, was significantly elevated. Of 8 patients with high levels of plasma IL-6, 4 patients died. In contrast, all 10 patients with low plasma IL-6 concentrations survived until day 28. Patients who died had constant high IL-6 concentrations during the first 3 days, whereas IL-6 levels in patients who survived decreased by 88%. Our data indicate that IL-6 levels are a better prognostic parameter in the early phase of sepsis than the monocyte HLA-DR expression.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 11:50:16