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Titolo:
Metabolic abnormalities and cardiovascular disease risk factors in adults with human immunodeficiency virus infection and lipodystrophy
Autore:
Hadigan, C; Meigs, JB; Corcoran, C; Rietschel, P; Piecuch, S; Basgoz, N; Davis, B; Sax, P; Stanley, T; Wilson, PWF; DAgostino, RB; Grinspoon, S;
Indirizzi:
Massachusetts Gen Hosp, Neuroendocrine Unit, Boston, MA 02114 USA Massachusetts Gen Hosp Boston MA USA 02114 ine Unit, Boston, MA 02114 USA Massachusetts Gen Hosp, Infect Dis Unit, Boston, MA 02114 USA Massachusetts Gen Hosp Boston MA USA 02114 Dis Unit, Boston, MA 02114 USA Massachusetts Gen Hosp, Div Gen Med, Boston, MA 02114 USA Massachusetts Gen Hosp Boston MA USA 02114 Gen Med, Boston, MA 02114 USA Massachusetts Gen Hosp, Combined Program Pediat Gastroenterol & Nutr, Boston, MA 02114 USA Massachusetts Gen Hosp Boston MA USA 02114 l & Nutr, Boston, MA 02114 USA Harvard Univ, Brigham & Womens Hosp, Sch Med, Infect Dis Unit, Cambridge, MA USA Harvard Univ Cambridge MA USA ch Med, Infect Dis Unit, Cambridge, MA USA Framingham Heart Study, Framingham, MA USA Framingham Heart Study Framingham MA USA Heart Study, Framingham, MA USA
Titolo Testata:
CLINICAL INFECTIOUS DISEASES
fascicolo: 1, volume: 32, anno: 2001,
pagine: 130 - 139
SICI:
1058-4838(20010101)32:1<130:MAACDR>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY HEART-DISEASE; ANTIRETROVIRAL THERAPY HAART; BETA-CELL FUNCTION; GLUCOSE-TOLERANCE; INSULIN-RESISTANCE; PROTEASE INHIBITORS; WOMEN; FAT; MODEL; HYPERLIPIDEMIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Grinspoon, S Massachusetts Gen Hosp, Neuroendocrine Unit, Bulfinch 457B, Boston, MA 02114 USA Massachusetts Gen Hosp Bulfinch 457B Boston MA USA 02114 USA
Citazione:
C. Hadigan et al., "Metabolic abnormalities and cardiovascular disease risk factors in adults with human immunodeficiency virus infection and lipodystrophy", CLIN INF D, 32(1), 2001, pp. 130-139

Abstract

We evaluated metabolic and clinical features of 71 HIV-infected patients with lipodystrophy by comparing them with 213 healthy control subjects, matched for age and body mass index, from the Framingham Offspring Study. Thirty HIV-infected patients without fat redistribution were compared separatelywith 90 matched control subjects from the Framingham Offspring Study. Fasting glucose, insulin, and lipid levels; glucose and insulin response to standard oral glucose challenge; and anthropometric measurements were determined. HIV-infected patients with lipodystrophy demonstrated significantly increased waist-to-hip ratios, fasting insulin levels, and diastolic blood pressure compared with controls. Patients with lipodystrophy were more likely to have impaired glucose tolerance, diabetes, hypertriglyceridemia, and reduced levels of high-density lipoprotein (HDL) cholesterol than were controls. With the exception of HDL cholesterol level, these risk factors for cardiovascular disease (CVD) were markedly attenuated in patients without lipodystrophy and were not significantly different in comparison with controls. These data demonstrate a metabolic syndrome characterized by profound insulin resistance and hyperlipidemia. CVD risk factors are markedly elevated inHIV-infected patients with fat redistribution.

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Documento generato il 05/04/20 alle ore 03:38:41