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Titolo:
Oral cefixime is similar to continued intravenous antibiotics in the empirical treatment of febrile neutropenic children with cancer
Autore:
Shenep, JL; Flynn, PM; Baker, DK; Hetherington, SV; Hudson, MM; Hughes, WT; Patrick, CC; Roberson, PK; Sandlund, JT; Santana, VM; Sixbey, JW; Slobod, KS;
Indirizzi:
St Jude Childrens Res Hosp, Dept Infect Dis, Memphis, TN 38105 USA St JudeChildrens Res Hosp Memphis TN USA 38105 is, Memphis, TN 38105 USA St Jude Childrens Res Hosp, Dept Hematol Oncol, Memphis, TN 38105 USA St Jude Childrens Res Hosp Memphis TN USA 38105 ol, Memphis, TN 38105 USA St Jude Childrens Res Hosp, Dept Pathol, Memphis, TN 38105 USA St Jude Childrens Res Hosp Memphis TN USA 38105 ol, Memphis, TN 38105 USA St Jude Childrens Res Hosp, Dept Pharmaceut Sci, Memphis, TN 38105 USA St Jude Childrens Res Hosp Memphis TN USA 38105 ci, Memphis, TN 38105 USA St Jude Childrens Res Hosp, Dept Biostat, Memphis, TN 38105 USA St Jude Childrens Res Hosp Memphis TN USA 38105 at, Memphis, TN 38105 USA Univ Tennessee, Ctr Hlth Sci, Coll Pharm, Memphis, TN 38163 USA Univ Tennessee Memphis TN USA 38163 ci, Coll Pharm, Memphis, TN 38163 USA Univ Tennessee, Ctr Hlth Sci, Dept Pediat, Memphis, TN 38163 USA Univ Tennessee Memphis TN USA 38163 i, Dept Pediat, Memphis, TN 38163 USA
Titolo Testata:
CLINICAL INFECTIOUS DISEASES
fascicolo: 1, volume: 32, anno: 2001,
pagine: 36 - 43
SICI:
1058-4838(20010101)32:1<36:OCISTC>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
EARLY HOSPITAL DISCHARGE; ANTIMICROBIAL THERAPY; FEVER; DISCONTINUATION; GRANULOCYTOPENIA; CHEMOTHERAPY; ADOLESCENTS; PROPHYLAXIS; MANAGEMENT; OFLOXACIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Shenep, JL St Jude Childrens Res Hosp, Dept Infect Dis, 332 N Lauderdale St, Memphis,TN 38105 USA St Jude Childrens Res Hosp 332 N Lauderdale St Memphis TN USA 38105
Citazione:
J.L. Shenep et al., "Oral cefixime is similar to continued intravenous antibiotics in the empirical treatment of febrile neutropenic children with cancer", CLIN INF D, 32(1), 2001, pp. 36-43

Abstract

Empiric oral antibiotic therapy for febrile neutropenic cancer patients has been suggested as a means to decrease hospitalization, but the safety of this approach has not been adequately studied in children. We compared continued iv antibiotic therapy with switching treatment to orally administeredcefixime in a group of selected febrile neutropenic children for whom blood cultures were sterile after 48 h of incubation. Two hundred episodes of febrile neutropenia were studied (156 patients), and 100 episodes were randomized to receive each treatment. Failure to respond to therapy was defined by documented or suspected bacterial infection, recurrent fever, or discontinuation of assigned therapy for any reason before neutropenia resolved. Rates of treatment failure were similar in the oral cefixime group (28%) and in the iv antibiotic group (27%; P=1.0). Results support the safety of oralcefixime therapy for low-risk febrile neutropenic children, a therapeutic approach that would facilitate earlier outpatient management and decrease the costs of treatment.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 20:49:41