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Titolo:
Toxoplasmosis, a severe complication in allogeneic hematopoietic stem celltransplantation: Successful treatment strategies during a 5-year single-center experience
Autore:
Roemer, E; Blau, IW; Basara, N; Kiehl, MG; Bischoff, M; Gunzelmann, S; Kirsten, D; Sanchez, H; Wocker, EL; Fauser, AA;
Indirizzi:
Univ Mainz, Teaching Hosp, Dept Bone Marrow Transplantat & Hematol Oncol, Idar Oberstein, Germany Univ Mainz Idar Oberstein Germany ematol Oncol, Idar Oberstein, Germany Univ Mainz, Teaching Hosp, Dept Radiol, Idar Oberstein, Germany Univ Mainz Idar Oberstein Germany Dept Radiol, Idar Oberstein, Germany
Titolo Testata:
CLINICAL INFECTIOUS DISEASES
fascicolo: 1, volume: 32, anno: 2001,
pagine: E1 - E8
SICI:
1058-4838(20010101)32:1<E1:TASCIA>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
BONE-MARROW TRANSPLANTATION; POLYMERASE-CHAIN-REACTION; ACQUIRED-IMMUNODEFICIENCY-SYNDROME; VIRUS-INFECTED PATIENTS; CEREBRAL TOXOPLASMOSIS; ENCEPHALITIS; RECIPIENTS; DIAGNOSIS; GONDII; AIDS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Roemer, E Univ Mainz, Teaching Hosp, Dept Bone Marrow Transplant & HematolOncol, DrOttmar Kohler Str 2, D-55743 Idar Oberstein, Germany Univ Mainz Dr Ottmar Kohler Str 2 Idar Oberstein Germany D-55743
Citazione:
E. Roemer et al., "Toxoplasmosis, a severe complication in allogeneic hematopoietic stem celltransplantation: Successful treatment strategies during a 5-year single-center experience", CLIN INF D, 32(1), 2001, pp. E1-E8

Abstract

Toxoplasmosis is a rare but often fatal complication that occurs after patients undergo allogeneic hematopoietic stem cell transplant. At our institution, toxoplasmosis was diagnosed in 8 of 301 patients who received stem cell transplants. Disseminated toxoplasmosis with a rapid fatal course was observed in 2 patients. Six patients had cerebral toxoplasmosis diagnosed on the basis of neurological signs and observation of the patients' mental confusion, seizures, and typical lesions (which were assessed by computed tomography, magnetic resonance imaging, or both). Seroconversion of antitoxoplasma immunoglobulin and a discovery of toxoplasma deoxyribonucleic acid in the cerebrospinal fluid (confirmed by use of polymerase chain reaction) weredocumented in all patients. Treatment consisted of clindamycin therapy (for 2 patients) and of pyrimethamine-clindamycin therapy, sulfadiazine therapy, or both (for 5 patients). Patients showed improvement after therapy, as assessed by clinical and radiological means. Three of 8 patients survive-1 without any residual neurological symptoms and 2 with minimal neurological symptoms.

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Documento generato il 29/11/20 alle ore 10:17:53