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Titolo:
Upper extremity deep vein thrombosis in a young patient double heterozygous for factor V Leiden and prothrombin G20210A mutation
Autore:
Vaya, A; Todoli, J; Ricart, J; Estelles, A; Mira, Y; Villa, P; Calabuig, JR; Aznar, J;
Indirizzi:
La Fe Univ Hosp, Dept Clin Pathol, Thrombosis & Hemostasis Unit, Valencia 46009, Spain La Fe Univ Hosp Valencia Spain 46009 ostasis Unit, Valencia 46009, Spain La Fe Univ Hosp, Res Ctr, Serv Internal Med, Valencia 46009, Spain La Fe Univ Hosp Valencia Spain 46009 Internal Med, Valencia 46009, Spain
Titolo Testata:
CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS
fascicolo: 1, volume: 7, anno: 2001,
pagine: 72 - 74
SICI:
1076-0296(200101)7:1<72:UEDVTI>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
VENOUS THROMBOEMBOLISM; RISK-FACTORS; 20210A/A;
Keywords:
upper extremity deep vein thrombosis; factor V Leiden; prothrombin G20210A; thrombophilia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
12
Recensione:
Indirizzi per estratti:
Indirizzo: Vaya, A La Fe Univ Hosp, Dept Clin Pathol, Thrombosis & Hemostasis Unit, Avda Campanar 21, Valencia 46009, Spain La Fe Univ Hosp Avda Campanar 21 Valencia Spain 46009 6009, Spain
Citazione:
A. Vaya et al., "Upper extremity deep vein thrombosis in a young patient double heterozygous for factor V Leiden and prothrombin G20210A mutation", CL APPL T-H, 7(1), 2001, pp. 72-74

Abstract

We report on a 19-year-old girl with upper extremity deep vein thrombosis after catheter indwelling whose thrombophilic study disclosed the coexistence of factor V Leiden and the prothrombin G20210A mutation. The family study identified five other members who were also heterozygous for both mutations. This is the first case of upper extremity deep vein thrombosis with theco-inheritance of both genetic defects. It provides further evidence that thrombophilic defects mostly require additional triggering factors to induce a thrombotic event and suggests that in young patients with this venous thrombotic location, a thrombophilic search should be performed even when there are other acquired thrombotic risk factors.

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Documento generato il 19/09/20 alle ore 18:20:15