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Titolo:
Chromosome regions enriched in hyperacetylated histone H4 are preferred sites for endonuclease- and radiation-induced breakpoints
Autore:
Martinez-Lopez, W; Folle, GA; Obe, G; Jeppesen, P;
Indirizzi:
Univ Republ, Fac Sci, Montevideo, Uruguay Univ Republ Montevideo Uruguay niv Republ, Fac Sci, Montevideo, Uruguay Inst Invest Biol Clemente Estable, Montevideo, Uruguay Inst Invest Biol Clemente Estable Montevideo Uruguay ontevideo, Uruguay Univ Essen Gesamthsch, Essen, Germany Univ Essen Gesamthsch Essen Germany iv Essen Gesamthsch, Essen, Germany MRC, Human Genet Unit, Edinburgh, Midlothian, Scotland MRC Edinburgh Midlothian Scotland Unit, Edinburgh, Midlothian, Scotland
Titolo Testata:
CHROMOSOME RESEARCH
fascicolo: 1, volume: 9, anno: 2001,
pagine: 69 - 75
SICI:
0967-3849(2001)9:1<69:CREIHH>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
HAMSTER OVARY CELLS; INTRACHROMOSOMAL LOCALIZATION; NUCLEAR ARCHITECTURE; GENE-EXPRESSION; ACETYLATION; CHROMATIN; CYCLE; ANTIBODIES; BAMHI; PHASE;
Keywords:
chromosome breakpoints; endonucleases; G-light bands; histone H4 hyperacetylation; ionizing radiation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Martinez-Lopez, W Univ Republ, Fac Sci, Montevideo, Uruguay Univ Republ Montevideo Uruguay i, Montevideo, Uruguay
Citazione:
W. Martinez-Lopez et al., "Chromosome regions enriched in hyperacetylated histone H4 are preferred sites for endonuclease- and radiation-induced breakpoints", CHROMOS RES, 9(1), 2001, pp. 69-75

Abstract

Previously, we have shown that breakpoints induced by the endonucleases AluI, BamHI and DNase I in CHO chromosomes are localized mainly in G-light bands. Neutrons and gamma rays produced similar breakpoint clusters to endonucleases in most CHO chromosomes. Here we compare endonuclease- and radiation-induced breakpoint maps with hyperacetylation patterns of histone H4. TheH4 acetylation pattern in chromosomes is similar to the pattern of G-light, or R-bands, and breakpoints are clustered in highly acetylated chromosomeregions. These findings indicate that chromosomal aberrations occur more frequently in active than in inactive chromatin.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 09:04:24