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Titolo:
High performance liquid chromatographic determination of fluvoxamine and paroxetine in plasma
Autore:
Skibinski, R; Misztal, G; Olajossy, M;
Indirizzi:
Med Acad, Dept Med Chem, PL-20093 Lublin, Poland Med Acad Lublin Poland PL-20093 , Dept Med Chem, PL-20093 Lublin, Poland Med Acad, Psychiat Clin, PL-20442 Lublin, Poland Med Acad Lublin Poland PL-20442 , Psychiat Clin, PL-20442 Lublin, Poland
Titolo Testata:
CHEMIA ANALITYCZNA
fascicolo: 6, volume: 45, anno: 2000,
pagine: 815 - 823
SICI:
0009-2223(2000)45:6<815:HPLCDO>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
ULTRAVIOLET DETECTION; AUTOMATED-DETERMINATION; FLUORESCENCE DETECTION; COLUMN;
Keywords:
paroxetine; fluvoxamine; HPLC; plasma; assay; solid-phase extraction;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
14
Recensione:
Indirizzi per estratti:
Indirizzo: Misztal, G Med Acad, Dept Med Chem, 6 Chodzki Str, PL-20093 Lublin, PolandMed Acad 6 Chodzki Str Lublin Poland PL-20093 3 Lublin, Poland
Citazione:
R. Skibinski et al., "High performance liquid chromatographic determination of fluvoxamine and paroxetine in plasma", CHEM ANAL, 45(6), 2000, pp. 815-823

Abstract

A rapid, simple and accurate method for the determination of paroxetine and fluvoxamine in human plasma is presented. Solid-phase extraction of thesesubstances was carried out using a LiChrolut RP-18 column. A methanol-tetrahydrofuran-phosphate buffer at pH 2.65 (0.0657 mol 1(-1)) (53:5:42, v/v) was used as the mobile phase. Determination was performed using isocratic reversed-phase high-performance liquid chromatography (HPLC) with a Nova-Pak C-18 column and UV detection at 293 nm and 253 nm. The lower limit of quantitation for paroxetine and fluvoxamine was 10 ng ml(-1), when 1 ml plasma was extracted. Accuracies calculated at three concentrations in each of three separate runs were between 93.6 and 104.7% for paroxetine and 91.8 and 102.2% for fluvoxamine, and precision data were from 5.8 to 7.9 for paroxetine and from 2.2 to 8.8 for fluvoxamine.

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Documento generato il 22/01/20 alle ore 06:39:59