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Titolo:
Follicular lesions of thyroid - A 5-year fine-needle aspiration experience
Autore:
Greaves, TS; Olvera, M; Florentine, BD; Raza, AS; Cobb, CJ; Tsao-Wei, DD; Groshen, S; Singer, P; Lopresti, J; Martin, SE;
Indirizzi:
Los Angeles Cty & Univ So Calif Healthcare Networ, Dept Pathol, Unit 1, Los Angeles, CA 90033 USA Los Angeles Cty & Univ So Calif Healthcare Networ Los Angeles CA USA 90033 Univ So Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA USA Univ SoCalif Los Angeles CA USA , Dept Prevent Med, Los Angeles, CA USA Los Angeles Cty & Univ So Calif Healthcare Networ, Dept Endocrinol & Diabet, Los Angeles, CA 90033 USA Los Angeles Cty & Univ So Calif Healthcare Networ Los Angeles CA USA 90033
Titolo Testata:
CANCER CYTOPATHOLOGY
fascicolo: 6, volume: 90, anno: 2000,
pagine: 335 - 341
SICI:
0008-543X(200012)90:6<335:FLOT-A>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
MALIGNANCY; NODULES;
Keywords:
follicular lesion; thyroid; cytology; fine-needle aspiration;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
10
Recensione:
Indirizzi per estratti:
Indirizzo: Greaves, TS Los Angeles Cty & Univ So Calif Healthcare Networ, Dept Pathol, Unit 1, Room 2900,1200 N State St, Los Angeles, CA 90033 USA Los Angeles Cty & Univ So Calif Healthcare Networ Room 2900,1200 N State St Los AngelesCA USA 90033
Citazione:
T.S. Greaves et al., "Follicular lesions of thyroid - A 5-year fine-needle aspiration experience", CANC CYTOP, 90(6), 2000, pp. 335-341

Abstract

BACKGROUND. Fine-needle aspiration (FNA) of the thyroid is of limited value in discriminating between nonneoplastic and neoplastic lesions in approximately 5-29% of patients. Indeterminate lesions are due primarily to the overlapping cytologic features found in follicular lesions. In this report, the authors describe their experience with FNA biopsy of the thyroid, concentrating on the analysis of those aspirates placed in the follicular lesion category. METHODS. A blinded, retrospective analysis of 92 patients who underwent FNA and were diagnosed with follicular lesions was performed by three of the authors (T.S.G., B.D.F., and M.O.) at a multihead microscope. A worksheet assessing a variety of cytologic arid architectural features was filled out for each FNA patient. The reviewers then reached a consensus diagnosis. RESULTS. The reviewers agreed with the reported FNA diagnosis of follicular lesion in 63 of the 92 patients studied. No distinguishing cytologic features predictive of the histologic outcome were found in any of these 63 patients. Seven patients were judged by the reviewers to have insufficient cells for evaluation. In the remaining 22 patients, the reviewers' diagnoses were in agreement with the histologic diagnoses in 17 patients. CONCLUSIONS. The authors found that there is a gray area in the cytologic diagnosis of patients with thyroid lesions by FNA due to inherent similarities at the light microscopic level. However, increased specificity may be achieved by careful attention to cytologic features and morphologic detail. Skillful application of FNA techniques, with the recovery of an adequate sample, will further decrease both interpretive errors and the number of patients diagnosed with "follicular lesions. " Cancer (Cancer Cytopathol) 2000;90:335-341. (C) 2000 American Cancer Society.

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Documento generato il 22/01/20 alle ore 18:37:23