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Titolo:
Allosteric inhibition of fructose-1,6-bisphosphatase by anilinoquinazolines
Autore:
Wright, SW; Hageman, DL; McClure, LD; Carlo, AA; Treadway, JL; Mathiowetz, AM; Withka, JM; Bauer, PH;
Indirizzi:
Pfizer Inc, Cent Res, Groton, CT 06340 USA Pfizer Inc Groton CT USA 06340Pfizer Inc, Cent Res, Groton, CT 06340 USA Pfizer Discovery Technol Ctr, Cambridge, MA 02139 USA Pfizer Discovery Technol Ctr Cambridge MA USA 02139 mbridge, MA 02139 USA
Titolo Testata:
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
fascicolo: 1, volume: 11, anno: 2001,
pagine: 17 - 21
SICI:
0960-894X(20010108)11:1<17:AIOFBA>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
GROWTH-FACTOR RECEPTOR; TYROSINE KINASE INHIBITORS; HUMAN LIVER FRUCTOSE-1,6-BISPHOSPHATASE; HEPATIC GLUCONEOGENESIS; AUTOMATED DOCKING; CRYSTAL-STRUCTURE; RAT-LIVER; PROTEIN; BINDING; POTENT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Wright, SW Pfizer Inc, Cent Res, Eastern Point Rd, Groton, CT 06340 USA Pfizer Inc Eastern Point Rd Groton CT USA 06340 n, CT 06340 USA
Citazione:
S.W. Wright et al., "Allosteric inhibition of fructose-1,6-bisphosphatase by anilinoquinazolines", BIOORG MED, 11(1), 2001, pp. 17-21

Abstract

Anilinoquinazolines currently of interest as inhibitors of tyrosine kinases have been found to be allosteric inhibitors of the enzyme fructose 1,6-bisphosphatase. These represent a new approach to inhibition of F16BPase and serve as leads for further drug design. Enzyme inhibition is achieved by binding at an unidentified allosteric site. (C) 2000 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 17:43:12