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Titolo:
The effects of noradrenergic activation of the nucleus tractus solitarius on memory and in potentiating norepinephrine release in the amygdala
Autore:
Williams, CL; Men, DS; Clayton, EC;
Indirizzi:
Univ Virginia, Dept Psychol, Charlottesville, VA 22904 USA Univ Virginia Charlottesville VA USA 22904 Charlottesville, VA 22904 USA
Titolo Testata:
BEHAVIORAL NEUROSCIENCE
fascicolo: 6, volume: 114, anno: 2000,
pagine: 1131 - 1144
SICI:
0735-7044(200012)114:6<1131:TEONAO>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
BETA-ADRENERGIC RECEPTORS; ARTERIAL BLOOD-PRESSURE; INTACT STRIA TERMINALIS; VAGUS NERVE; BASOLATERAL AMYGDALA; AREA POSTREMA; CATECHOLAMINERGIC NEURONS; VAGAL AFFERENTS; RAT NUCLEUS; PERIPHERAL EPINEPHRINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
65
Recensione:
Indirizzi per estratti:
Indirizzo: Williams, CL Univ Virginia, Dept Psychol, 102 Gilmer Hall,POB 400400, Charlottesville, VA 22904 USA Univ Virginia 102 Gilmer Hall,POB 400400 Charlottesville VA USA 22904
Citazione:
C.L. Williams et al., "The effects of noradrenergic activation of the nucleus tractus solitarius on memory and in potentiating norepinephrine release in the amygdala", BEHAV NEURO, 114(6), 2000, pp. 1131-1144

Abstract

Although it is known that norepinephrine (NE) modulates memory by acting on limbic areas, few studies describe how structures supplying NE to the limbic system, such as the nucleus tractus solitarius (NTS) contribute to thisprocess. The present study examined the effects on memory of activating the NE pathway between the NTS and the amygdala (AMYG). Rats received buffer or the P-noradrenergic agonist clenbuterol (CLN; 10, 50, or 100 ng/0.5 mul)into the NTS after footshock training in a Y-maze discrimination task. Infusion of 100 ng CLN significantly improved memory when retention was testedin the absence or presence of cues associated with the footshock. Experiment 2 used in vivo microdialysis to determine whether the mnemonic effects of CLN are mediated by influencing NE output in the AMYG. Subjects were given an intra-NTS infusion of CLN or phosphate buffered saline, footshock (0.8mA, 1 s), and injected with epinephrine (EPI; 0.3 mg/kg ip) or saline. CLNor EPI injection produced a significant increase in NE sampled from the AMYG. These findings indicate that activation of NTS neurons that project to and release NE in the AMYG modulates memory storage processing.

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Documento generato il 06/04/20 alle ore 01:19:04