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Titolo:
Differential role of the medial and lateral prefrontal cortices in fear and anxiety
Autore:
Lacroix, L; Spinelli, S; Heidbreder, CA; Feldon, J;
Indirizzi:
Swiss Fed Inst Technol, Behav Neurobiol Lab, CH-8603 Schwerzenbach, Switzerland Swiss Fed Inst Technol Schwerzenbach Switzerland CH-8603 ch, Switzerland
Titolo Testata:
BEHAVIORAL NEUROSCIENCE
fascicolo: 6, volume: 114, anno: 2000,
pagine: 1119 - 1130
SICI:
0735-7044(200012)114:6<1119:DROTMA>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
ELEVATED PLUS-MAZE; PRELIMBIC-INFRALIMBIC AREAS; NUCLEUS-ACCUMBENS; ANIMAL-MODELS; RECIPROCAL CONNECTIONS; BASOLATERAL AMYGDALA; POTENTIATED STARTLE; EXCITOTOXIC LESIONS; ANTERIOR CINGULATE; FREEZING BEHAVIOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
69
Recensione:
Indirizzi per estratti:
Indirizzo: Feldon, J Swiss Fed Inst Technol, Behav Neurobiol Lab, Schorenstr 16, CH-8603 Schwerzenbach, Switzerland Swiss Fed Inst Technol Schorenstr 16 Schwerzenbach Switzerland CH-8603
Citazione:
L. Lacroix et al., "Differential role of the medial and lateral prefrontal cortices in fear and anxiety", BEHAV NEURO, 114(6), 2000, pp. 1119-1130

Abstract

In the rat, both the medial and lateral prefrontal cortices (PFC; mPFC andlPFC, respectively) have direct connections with limbic structures that are important in the expression of fear and anxiety. The present study investigated the behavioral effects of excitotoxic lesions of either the mPFC or the lPFC on conditioned and unconditioned fear paradigms. In both unconditioned fear paradigms (open field, elevated plus-maze), lesions of the mPFC decreased anxiety. In fear conditioning, lPFC lesions substantially increased freezing throughout the different phases of the experiment, whereas mPFC lesions increased freezing to contextual cues and showed reduced freezing to discrete cues. These results support the functional role of the PFC in mediating or modulating central stares of fear and anxiety and suggest a functional dissociation between the lPFC and mPFC in their role in fear and anxiety.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 12:23:38