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Titolo:
Involvement of NMDA receptors within the amygdala in short- versus long-term memory for fear conditioning as assessed with fear-potentiated startle
Autore:
Walker, DL; Davis, M;
Indirizzi:
Emory Univ, Sch Med, Dept Psychiat & Behav Sci, Atlanta, GA 30322 USA Emory Univ Atlanta GA USA 30322 ychiat & Behav Sci, Atlanta, GA 30322 USA
Titolo Testata:
BEHAVIORAL NEUROSCIENCE
fascicolo: 6, volume: 114, anno: 2000,
pagine: 1019 - 1033
SICI:
0735-7044(200012)114:6<1019:IONRWT>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
SPATIAL-LEARNING TASK; D-ASPARTATE RECEPTORS; BASOLATERAL AMYGDALA; SYNAPTIC PLASTICITY; TEMPORAL GRADIENT; INHIBITORY AVOIDANCE; SHOCK SENSITIZATION; RETROGRADE-AMNESIA; RAT HIPPOCAMPUS; CENTRAL NUCLEUS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
59
Recensione:
Indirizzi per estratti:
Indirizzo: Walker, DL Emory Univ, Sch Med, Dept Psychiat & Behav Sci, 1639 Pierce Dr,Suite 4000,Atlanta, GA 30322 USA Emory Univ 1639 Pierce Dr,Suite 4000 Atlanta GA USA 30322 2 USA
Citazione:
D.L. Walker e M. Davis, "Involvement of NMDA receptors within the amygdala in short- versus long-term memory for fear conditioning as assessed with fear-potentiated startle", BEHAV NEURO, 114(6), 2000, pp. 1019-1033

Abstract

Pretraining intra-amygdala infusions of the NMDA receptor antagonist, D,L-AP5, block fear-potentiated startle in rats tested 24+ hr after training. This may reflect a failure of either acquisition or retention. To evaluate these alternatives, rats were tested for fear-potentiated startle during fear conditioning (30 light-shock pairings [0.6 mA shock]), as well as 1-30 min and 48 hr after fear conditioning. Amygdala lesions abolished fear-potentiated startle at all train-test intervals. Intra-amygdala AP5 infusions (25nmol/side) abolished fear-potentiated startle during the long-term test and had partial effects at shorter train-test intervals. When the level of fear-potentiated startle during the short-term test was lowered to that of the 48-hr test (i.e., by training rats with a lower, 0.3 mA footshock), AP5 abolished fear-potentiated startle at each timepoint. Thus, amygdala NMDA receptors appear to participate in the initial acquisition of fear memories.

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Documento generato il 28/09/20 alle ore 15:23:58