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Titolo:
Evidence for progression of brain structural abnormalities in schizophrenia: beyond the neurodevelopmental model
Autore:
Velakoulis, D; Wood, SJ; McGorry, PD; Pantelis, C;
Indirizzi:
Sunshine Hosp, St Albans, Vic 3021, Australia Sunshine Hosp St Albans VicAustralia 3021 St Albans, Vic 3021, Australia Univ Melbourne, Cognit Neuropsychiat Res & Acad Unit, St Albans, Vic, Australia Univ Melbourne St Albans Vic Australia d Unit, St Albans, Vic, Australia Univ Melbourne, Dept Psychiat, Mental Hlth Serv Kids & Youth, Melbourne, Vic, Australia Univ Melbourne Melbourne Vic Australia Youth, Melbourne, Vic, Australia
Titolo Testata:
AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY
, volume: 34, anno: 2000, supplemento:, S
pagine: S113 - S126
SICI:
0004-8674(200011)34:<S113:EFPOBS>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHILDHOOD-ONSET SCHIZOPHRENIA; FIRST-EPISODE SCHIZOPHRENIA; SUPERIOR TEMPORAL GYRUS; TREATMENT-RESISTANT SCHIZOPHRENIA; CEREBRAL VENTRICULAR ENLARGEMENT; BIPOLAR AFFECTIVE-DISORDER; FOLLOW-UP; BASAL GANGLIA; HIPPOCAMPAL VOLUME; PREFRONTAL CORTEX;
Keywords:
high risk; hippocampus; longitudinal; neurodegeneration; psychosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Citazioni:
105
Recensione:
Indirizzi per estratti:
Indirizzo: Velakoulis, D Sunshine Hosp, 176 Furlong Rd, St Albans, Vic 3021, Australia Sunshine Hosp 176 Furlong Rd St Albans Vic Australia 3021 ia
Citazione:
D. Velakoulis et al., "Evidence for progression of brain structural abnormalities in schizophrenia: beyond the neurodevelopmental model", AUST NZ J P, 34, 2000, pp. S113-S126

Abstract

Objective: Clinical, neuroimaging, neuropathological and neuropsychological evidence suggests that, in schizophrenia, there is structural and functional disturbance of the hippocampus. The purpose of this paper is to presentpublished findings concerning the nature, timing and course of these putative disturbances of hippocampal function and the pathophysiological mechanisms involved, and to explore whether schizophrenia is a disorder of neurodevelopment, neurodegeneration or a combination of both processes. Method: The available cross-sectional and longitudinal evidence for hippocampal involvement in schizophrenia is reviewed and a model of hippocampal involvement in this disorder, which derives from our own cross-sectional andlongitudinal hippocampal imaging data, is described. Results: We propose a three-hit model in which an early neurodevelopmentallesion renders the hippocampus vulnerable to further insult later in life during the transition phase to active illness. The available evidence suggests that the left hippocampus is particularly vulnerable during these earlystages, while further insult involving the hippocampus bilaterally occurs in those who develop a chronic form of the illness. Conclusions: Intervention strategies should target the most vulnerable stages of the illness, in particular the transition phase to psychosis, when novel treatments may prevent the illness or ameliorate its effects.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 01:13:08