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Titolo:
Biological markers and schizophrenia
Autore:
Copolov, D; Crook, J;
Indirizzi:
Mental Hlth Res Inst Victoria, Parkville, Vic 3052, Australia Mental Hlth Res Inst Victoria Parkville Vic Australia 3052 052, Australia NIMH, Clin Brain Disorders Branch, Bethesda, MD 20892 USA NIMH Bethesda MD USA 20892 Brain Disorders Branch, Bethesda, MD 20892 USA
Titolo Testata:
AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY
, volume: 34, anno: 2000, supplemento:, S
pagine: S108 - S112
SICI:
0004-8674(200011)34:<S108:BMAS>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
HOMOVANILLIC-ACID CONCENTRATIONS; POSITRON EMISSION TOMOGRAPHY; D2 DOPAMINE-RECEPTORS; CEREBROSPINAL-FLUID; HEALTHY CONTROLS; OCULOMOTOR ABNORMALITIES; MONOAMINE METABOLITES; HALOPERIDOL CHALLENGE; PROLACTIN RESPONSE; CSF LEVELS;
Keywords:
biological markers; dopamine; homovanillic acid; review; schizophrenia; smooth pursuit eye movements; ventricles;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Copolov, D Mental Hlth Res Inst Victoria, Locked Bag 11, Parkville, Vic 3052, Australia Mental Hlth Res Inst Victoria Locked Bag 11 Parkville Vic Australia 3052
Citazione:
D. Copolov e J. Crook, "Biological markers and schizophrenia", AUST NZ J P, 34, 2000, pp. S108-S112

Abstract

Objective: The delivery of biological markers for schizophrenia would greatly assist preventative strategies by identifying at-risk individuals who could then be monitored and treated in a manner with a view to minimising subsequent morbidity. This paper aims to present a selection of biological measures that may indicate risk of schizophrenia. Method: A selective and brief review is provided of intensively studied putative markers, including enlarged cerebral ventricles, dopamine D-2 receptor density, amphetamine-stimulated central nervous system dopamine release,plasma homovanillic acid and smooth pursuit eye tracking dysfunction. Results: A number of biological measures have been reported to be correlated with schizophrenia. Conclusions: Presently, none of these measures has satisfactory performance characteristics in terms of predictive validity, noninvasiveness, ease oftesting and low cost that would enable their widespread use. However, a few have potential for further investigation and development.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/11/20 alle ore 14:15:09