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Titolo:
Low levels of cadmium chloride alter the immunoprecipitation of corneal cadherin-complex proteins
Autore:
Weidner, WJ; Waddell, DS; Sillman, AJ;
Indirizzi:
Univ Calif Davis, Div Biol Sci, Sect Neurobiol Physiol & Behav, Davis, CA 95616 USA Univ Calif Davis Davis CA USA 95616 Physiol & Behav, Davis, CA 95616 USA
Titolo Testata:
ARCHIVES OF TOXICOLOGY
fascicolo: 10, volume: 74, anno: 2000,
pagine: 578 - 581
SICI:
0340-5761(200012)74:10<578:LLOCCA>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
VASCULAR ENDOTHELIAL-CELLS; LLC-PK1 CELLS; JUNCTIONS; CD2+; DAMAGE;
Keywords:
cornea; cadmium chloride; endothelium; adhesion molecules; cadherins;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Weidner, WJ Univ Calif Davis, Div Biol Sci, Sect Neurobiol Physiol & Behav, 1 Shields Ave, Davis, CA 95616 USA Univ Calif Davis 1 Shields Ave Davis CA USA 95616 CA 95616 USA
Citazione:
W.J. Weidner et al., "Low levels of cadmium chloride alter the immunoprecipitation of corneal cadherin-complex proteins", ARCH TOXIC, 74(10), 2000, pp. 578-581

Abstract

The effect of cadmium chloride on the immunoprecipitation of cadherin and the associated adherens junctional proteins, alpha- and beta -catenin, was examined in isolated bullfrog (Rana catesbeiana) corneas utilizing Western blot and enhanced chemoluminescent techniques. Application of either 1.0 muM or 75.0 muM CdCl2 to the corneal endothelium for 2 h markedly decreased the immunoprecipitation of cadherins as compared to paired control corneas. Immunoprecipitation of alpha -catenin was increased in response to both doses of CdCl2, while the immunoprecipitation of beta -catenin was little changed by either cadmium dose. There is accumulating evidence that cadmium mayincrease epithelial paracellular permeability by interfering with cadherincomplex activity at intercellular junctions. The present study suggests that inorganic cadmium in low micromolar concentrations may decrease the integrity of the corneal endothelium, at least in part through a similar mechanism involving disruption of junctional cadherin complex function.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/10/20 alle ore 16:23:40