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Titolo:
Epithelial M cells: Differentiation and function
Autore:
Kraehenbuhl, JP; Neutra, MR;
Indirizzi:
Univ Lausanne, Swiss Inst Expt Canc Res, CH-1066 Epalinges, Switzerland Univ Lausanne Epalinges Switzerland CH-1066 -1066 Epalinges, Switzerland Univ Lausanne, Inst Biochem, CH-1066 Epalinges, Switzerland Univ LausanneEpalinges Switzerland CH-1066 -1066 Epalinges, Switzerland Childrens Hosp, Boston, MA 02115 USA Childrens Hosp Boston MA USA 02115Childrens Hosp, Boston, MA 02115 USA Harvard Univ, Sch Med, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 vard Univ, Sch Med, Boston, MA 02115 USA
Titolo Testata:
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY
, volume: 16, anno: 2000,
pagine: 301 - 332
SICI:
1081-0706(2000)16:<301:EMCDAF>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; INTESTINAL M-CELLS; FOLLICLE-ASSOCIATED EPITHELIUM; ENTEROPATHOGENIC ESCHERICHIA-COLI; PERIPHERAL LYMPHOID ORGANS; MOUSE PEYERS PATCH; LYMPHOTOXIN-BETA-RECEPTOR; MONOCLONAL IGA ANTIBODIES; SALMONELLA-TYPHIMURIUM; VIBRIO-CHOLERAE;
Keywords:
M cells; Peyer's patches; mucosal immunity; epithelium; microorganisms;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
163
Recensione:
Indirizzi per estratti:
Indirizzo: Kraehenbuhl, JP Univ Lausanne, Swiss Inst Expt Canc Res, CH-1066 Epalinges, Switzerland Univ Lausanne Epalinges Switzerland CH-1066 Switzerland
Citazione:
J.P. Kraehenbuhl e M.R. Neutra, "Epithelial M cells: Differentiation and function", ANN R C DEV, 16, 2000, pp. 301-332

Abstract

M cells are distinctive epithelial cells that occur only in the follicle-associated epithelia that overlie organized mucosa-associated lymphoid tissues. They are structurally and functionally specialized for transepithelial transport, delivering foreign antigens and microorganisms to organized lymphoid tissues within the mucosae of the small and large intestines, tonsils and adenoids, and airways. M cell transport is a double-edged sword: Certain pathogens exploit the features of M cells that are intended to promote uptake for the purpose of immunological sampling. Eludication of the molecular architecture of M cell apical surfaces is important for understanding thestrategies that pathogens use to exploit this pathway and for utilizing M cell transport for delivery of vaccines to the mucosal immune system. This article reviews the functional and biochemical features that distinguish M cells from other intestinal cell types. In addition it synthesizes the available information on development and differentiation of organized lymphoid tissues and the specialized epithelium associated with these immune inductive sites.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 21:47:41