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Titolo:
Autoimmune hemolytic anemia in patients with non-Hodgkin's lymphoma: Characteristics and significance
Autore:
Sallah, S; Sigounas, G; Vos, P; Wan, JY; Nguyen, NP;
Indirizzi:
Univ Tennessee, Dept Med, Div Hematol Oncol, Memphis, TN 38163 USA Univ Tennessee Memphis TN USA 38163 Hematol Oncol, Memphis, TN 38163 USA E Carolina Univ, Dept Prevent Med, Greenville, NC USA E Carolina Univ Greenville NC USA , Dept Prevent Med, Greenville, NC USA E Carolina Univ, Div Hematol Oncol & Bone Marrow Transplantat, Greenville,NC USA E Carolina Univ Greenville NC USA Marrow Transplantat, Greenville,NC USA Univ Tennessee, Dept Biostat, Memphis, TN 38163 USA Univ Tennessee Memphis TN USA 38163 , Dept Biostat, Memphis, TN 38163 USA SW Univ, Dept Radiat Oncol, Dallas, TX USA SW Univ Dallas TX USASW Univ, Dept Radiat Oncol, Dallas, TX USA
Titolo Testata:
ANNALS OF ONCOLOGY
fascicolo: 12, volume: 11, anno: 2000,
pagine: 1571 - 1577
SICI:
0923-7534(200012)11:12<1571:AHAIPW>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHRONIC LYMPHOCYTIC-LEUKEMIA; V-GENE EXPRESSION; T-CELL LYMPHOMAS; ANGIOIMMUNOBLASTIC LYMPHADENOPATHY; AUTOANTIBODIES; DYSPROTEINEMIA; PATHOGENESIS; MUTATIONS; CD5;
Keywords:
autoimmune hemolytic anemia; non-Hodgkin's lymphoma; treatment;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Sallah, S Univ Tennessee, Coll Med, Dept Hematol Oncol, 3 N Dunlap, Memphis, TN 38163 USA Univ Tennessee 3 N Dunlap Memphis TN USA 38163 his, TN 38163 USA
Citazione:
S. Sallah et al., "Autoimmune hemolytic anemia in patients with non-Hodgkin's lymphoma: Characteristics and significance", ANN ONCOL, 11(12), 2000, pp. 1571-1577

Abstract

Background: The occurrence of autoimmune hemolytic anemia (AIHA) in patients with non-Hodgkin's lymphoma (NHL) is well known. However, there is lack of information in the literature in terms of the significance and impact ofsuch phenomenon on the clinical course of these patients. Patients and methods: We analyzed the clinical and laboratory features, course and response of 16 patients with non-Hodgkin's lymphoma (NHL) and autoimmune hemolytic anemia (AIHA). Patients with small lymphocytic lymphoma and angioimmunoblastic lymphadenopathy with dysproteinemia were excluded fromthe analysis. The significance of certain parameters, such as cell type (B- vs. T-cell),stage of NHL and presence of serum monoclonal immunoglobulin were examined. The cohort consisted of 501 patients with NHL evaluated during the study period. Results: The response rate for the group of patients with NHL/AIHA and forthe cohort was 44% and 62%, respectively; P = 0.0138. T-cell histology wasoverrepresented in the patients with AIHA/NHL (33% vs. 14%; P = 0.048). The occurrence of AIHA was not statistically significant among the four stages of NHL (P = 0.722), while a significantly higher proportion of patients with AIHA had serum monoclonol gammopathy when compared to the cohort (25% vs. 8%; P = 0.03). The patients with NHL who did not develop AIHA had betteroverall survival and median survival compared to the NHL/AIHA group (P = 0.006 and P = 0.0001, respectively). Conclusions: The study provides for the first time a descriptive clinicopathologic analysis of patients with AIHA and NHL. Certain pathologic and laboratory features were more likely to be associated with the occurrence of AIHA in patients with NHL. Most importantly, was the adverse impact of AIHA on the survival of patients with NHL. Therefore, this finding should be taken in consideration when risk-stratifying patients with NHL.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 10:13:16