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Titolo:
Follicular large cell lymphoma: Long-term follow-up of 62 patients treatedbetween 1973-1981
Autore:
Rodriguez, J; McLaughlin, P; Fayad, L; Santiago, M; Hess, M; Rodriguez, MA; Romaguera, J; Hagemeister, F; Kantarjian, H; Cabanillas, F;
Indirizzi:
Univ Texas, MD Anderson Canc Ctr, Houston, TX 77030 USA Univ Texas Houston TX USA 77030 Anderson Canc Ctr, Houston, TX 77030 USA
Titolo Testata:
ANNALS OF ONCOLOGY
fascicolo: 12, volume: 11, anno: 2000,
pagine: 1551 - 1556
SICI:
0923-7534(200012)11:12<1551:FLCLLF>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
NODULAR HISTIOCYTIC LYMPHOMA; NON-HODGKINS-LYMPHOMA; LOW-GRADE; INTERNATIONAL INDEX; PROGNOSTIC FACTORS; FEATURES; CHEMOTHERAPY;
Keywords:
follicle center lymphoma; follicular; follicular large cell lymphoma; follicular lymphoma; grade 3;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: McLaughlin, P Univ Texas, MD Anderson Canc Ctr, 1515 Holcombe Blvd,Box 68,Houston, TX 77030 USA Univ Texas 1515 Holcombe Blvd,Box 68 Houston TX USA 77030 SA
Citazione:
J. Rodriguez et al., "Follicular large cell lymphoma: Long-term follow-up of 62 patients treatedbetween 1973-1981", ANN ONCOL, 11(12), 2000, pp. 1551-1556

Abstract

Purpose: Investigators disagree on whether follicular large cell lymphoma (FLCL) behaves like other follicular lymphomas, with no plateau in the survival curve, or as a more aggressive but potentially curable lymphoma. We reported in 1984 results for 62 FLCL patients treated at our institution; thecurrent report updates those results. Patients and methods: Sixty-two patients referred from 1973-1981, including fifteen (24%) patients with Ann Arbor stage I-II and forty-seven (76%) with stage III-IV FLCL. Seven patients received radiation (XRT) alone, forty patients XRT and chemotherapy, and fifteen patients received chemotherapy alone. Results: The median follow-up was 14.7 years. The median survival was 5.1 years, with 21% alive at 15 years. The failure-free survival (FFS) at 10 years was 31%. Univariate analysis revealed that age, Ann Arbor stage, and the International Index correlated with survival. Performance status, number of platelets, and LDH correlated with failure-free survival. Conclusions: FLCL responds to doxorubicin-based regimens similarly to diffuse large cell lymphoma. Patients with FLCL have the potential for prolonged failure-free survival. Variables that predict the survival in aggressive lymphomas apply as well in this type of lymphoma.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 10:58:06