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Titolo:
Recruitment experience in the first phase of the African American Hereditary Prostate Cancer (AAHPC) Study
Autore:
Royal, C; Baffoe-Bonnie, A; Kittles, R; Powell, I; Bennett, J; Hoke, G; Pettaway, C; Weinrich, S; Vijayakumar, S; Ahaghotu, C; Mason, T; Johnson, E; Obeikwe, M; Simpson, C; Mejia, R; Boykin, W; Roberson, P; Frost, J; Faison-Smith, L; Meegan, C; Foster, N; Furbert-Harris, P; Carpten, J; Bailey-Wilson, J; Trent, J; Berg, K; Dunston, G; Collins, F;
Indirizzi:
Howard Univ, Natl Human Genome Ctr, Washington, DC 20059 USA Howard Univ Washington DC USA 20059 Genome Ctr, Washington, DC 20059 USA NHGRI, NIH, Bethesda, MD USA NHGRI Bethesda MD USANHGRI, NIH, Bethesda, MD USA Fox Chase Canc Ctr, Philadelphia, PA 19111 USA Fox Chase Canc Ctr Philadelphia PA USA 19111 , Philadelphia, PA 19111 USA Wayne State Univ, Detroit, MI USA Wayne State Univ Detroit MI USAWayne State Univ, Detroit, MI USA Midtown Urol, Atlanta, GA USA Midtown Urol Atlanta GA USAMidtown Urol, Atlanta, GA USA Columbia Presbyterian Med Ctr, New York, NY 10032 USA Columbia Presbyterian Med Ctr New York NY USA 10032 ew York, NY 10032 USA Univ Texas, MD Anderson Canc Ctr, Houston, TX 77030 USA Univ Texas Houston TX USA 77030 Anderson Canc Ctr, Houston, TX 77030 USA Univ S Carolina, Columbia, SC 29208 USA Univ S Carolina Columbia SC USA 29208 S Carolina, Columbia, SC 29208 USA Univ Chicago Univ Illinois, Ctr Radiat Therapy, Michael Reese Hosp, Chicago, IL USA Univ Chicago Univ Illinois Chicago IL USA el Reese Hosp, Chicago, IL USA Univ Illinois, Chicago, IL USA Univ Illinois Chicago IL USAUniv Illinois, Chicago, IL USA
Titolo Testata:
ANNALS OF EPIDEMIOLOGY
fascicolo: 8, volume: 10, anno: 2000, supplemento:, S
pagine: S68 - S77
SICI:
1047-2797(200011)10:8<S68:REITFP>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-GENOME-PROJECT; CLINICAL-TRIALS; SUSCEPTIBILITY LOCUS; PARTICIPATION; POPULATIONS; CHROMOSOME; PREVENTION; TUSKEGEE; SYSTEM; RISK;
Keywords:
African American; prostate cancer; genetics;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Royal, C Howard Univ, Natl Human Genome Ctr, 2216 6th St NW,Room 207, Washington, DC 20059 USA Howard Univ 2216 6th St NW,Room 207 Washington DC USA 20059 9 USA
Citazione:
C. Royal et al., "Recruitment experience in the first phase of the African American Hereditary Prostate Cancer (AAHPC) Study", ANN EPIDEMI, 10(8), 2000, pp. S68-S77

Abstract

The African American Hereditary Prostate Cancer (AAHPC) Study is an ongoing multicenter genetic linkage study organized by Howard University and the National Human Genome Research Institute (NHGRI), with support from the Office for Research on Minority Health and the National Cancer institute. The goals of the study are to: (i) look for evidence of involvement of chromosome 1q24-25 (HPC1) in African American men with hereditary prostate cancer (HPC) and (ii) conduct a genome wide search for other loci associated with HPC in African American men. To accomplish these goals, a network has been established including Howard University, the NHGRI, and sh Collaborative Recruitment Centers (CRCs). The CRCs are responsible for the identification and enrollment of 100 African American families. To date, 43 families have been enrolled. Recruitment strategies have included mass media campaigns, physician referrals, community health-fairs/prostate cancer screenings, support groups, tumor registries, as well as visits to churches, barber shops, and universities. By far, the most productive recruitment mechanisms have been physician referrals and tumor registries, yielding a total of 35 (81%) families. Approximately 41% (n = 3400) of probands initially contacted by phone or mail expressed interest in participating; the families of 2% of thesemel the eligibility criteria, and 75% of those families have been enrolledin the study, indicating a 0.5% recruitment yield (ratio of participants to contacts). As the first large-scale genetic linkage study of African Americans, on a common disease, the challenges and successes of the recruitmentprocess for the AAHPC Study should serve to inform future efforts to involve this population in similar studies. (C) 2000 Elsevier Science Inc. All rights reserved.

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Documento generato il 15/01/21 alle ore 21:56:44