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Titolo:
SUBSTANCE P(6-11) AND NATURAL TACHYKININS INTERACT WITH SEPTIDE-SENSITIVE TACHYKININ RECEPTORS COUPLED TO A PHOSPHOLIPASE-C IN THE RAT URINARY-BLADDER
Autore:
TORRENS Y; SAFFROY M; GLOWINSKI J; BEAUJOUAN JC;
Indirizzi:
COLL FRANCE,INSERM U114,CHAIRE NEUROPHARMACOL,11 PL MARCELIN BERTHELOT F-75231 PARIS 05 FRANCE
Titolo Testata:
Neuropeptides
fascicolo: 3, volume: 31, anno: 1997,
pagine: 243 - 251
SICI:
0143-4179(1997)31:3<243:SPANTI>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
GUINEA-PIG ILEUM; NK1 RECEPTOR; P-RECEPTOR; SELECTIVE AGONISTS; BINDING-SITES; NEUROKININ RECEPTORS; ANTAGONISTS; RP-67580; BRAIN; HYDROLYSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
Y. Torrens et al., "SUBSTANCE P(6-11) AND NATURAL TACHYKININS INTERACT WITH SEPTIDE-SENSITIVE TACHYKININ RECEPTORS COUPLED TO A PHOSPHOLIPASE-C IN THE RAT URINARY-BLADDER", Neuropeptides, 31(3), 1997, pp. 243-251

Abstract

The rat urinary bladder possesses NK1, NK2 (but not NK3) and 'septide-sensitive' tachykinin receptors coupled to a phospholipase C. The present study performed with SR48968 (10(-6) M) to avoid any interaction of the tested peptides with NK2 receptors, indicates that substance P(6-11) (with a high potency), neurokinin A, neurokinin B and to a lesser extent neuropeptide K (with a lower potency) stimulate [H-3]-inositol monophosphate ([H-3]-IP1) formation in this tissue by acting on the 'septide-sensitive' tachykinin receptors. Substance P(6-11) had littleaffinity for NK1 binding sites and stimulated [H-3]-IP1 formation with an EC50 value and a maxima[ amplitude similar to those of septide. As previously observed with septide, this maximal response of substanceP(6-11)) (insensitive to 10(-6) M SR48968) which was about three-foldthat of substance P, was blocked by the NK1 receptor antagonist RP67580 and prevented by [Pro(9)]substance P (NK, receptor agonist). Similarly, substance P and several substance P C-terminal fragments prevented the substance P(6-11)-evoked response. In addition, neurokinin A, neuropeptide K and neurokinin B induced SR48968-resistant responses which exhibited a maximal amplitude similar to that of substance P (6-11) and were blocked by RP67580 and totally or partially (neuropeptide K) prevented by [Pro(9)]substance P.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 03:47:31