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Titolo:
Variable cytochrome P450 2D6 expression and metabolism of codeine and other opioid prodrugs: Implications for the Australian anaesthetist
Autore:
Wilcox, RA; Owen, H;
Indirizzi:
Flinders Univ S Australia, Flinders Med Ctr, Dept Anaesthesia, Bedford Pk,SA 5042, Australia Flinders Univ S Australia Bedford Pk SA Australia 5042 SA 5042, Australia
Titolo Testata:
ANAESTHESIA AND INTENSIVE CARE
fascicolo: 6, volume: 28, anno: 2000,
pagine: 611 - 619
SICI:
0310-057X(200012)28:6<611:VCP2EA>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
O-DEMETHYLATION; RAT-BRAIN; CYP2D6 PHENOTYPE; N-DEMETHYLATION; GENETIC-POLYMORPHISM; MORPHINE FORMATION; POOR METABOLIZERS; RECEPTOR-BINDING; LIVER-DISEASE; DEBRISOQUINE;
Keywords:
analgesics; opioid : codeine, tramadol, hydrocodone, ethylmorphine, oxycodone; enzymes : cytochrome P450 2D6;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
102
Recensione:
Indirizzi per estratti:
Indirizzo: Owen, H Flinders Univ S Australia, Flinders Med Ctr, Dept Anaesthesia, Bedford Pk,SA 5042, Australia Flinders Univ S Australia Bedford Pk SA Australia 5042 Australia
Citazione:
R.A. Wilcox e H. Owen, "Variable cytochrome P450 2D6 expression and metabolism of codeine and other opioid prodrugs: Implications for the Australian anaesthetist", ANAESTH I C, 28(6), 2000, pp. 611-619

Abstract

Codeine is a popular opioid prodrug dependent on the activity of the specific cytochrome P450 enzyme 206 (CYP2D6). This enzyme catalyses the production of the potent analgesic metabolite morphine, but genetic studies have demonstrated that individuals from different ethnic groups exhibit considerable variability in the functional capacities of their expressed CYP2D6 enzymes, and pharmacological studies have shown many commonly prescribed drugs can reduce the action of CYP2D6 enzymes. These findings have significant clinical implications for the rational prescription of effective analgesia, especially in a multicultural country like Australia.6

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 16:42:20