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Titolo:
Cytochrome P-450 as a source of catalytic iron in minimal change nephroticsyndrome in rats
Autore:
Liu, H; Shah, SV; Baliga, R;
Indirizzi:
Univ Mississippi, Med Ctr, Dept Pediat, Div Nephrol, Jackson, MS 39216 USAUniv Mississippi Jackson MS USA 39216 Div Nephrol, Jackson, MS 39216 USA Univ Arkansas Med Sci, Dept Med, Little Rock, AR 72205 USA Univ Arkansas Med Sci Little Rock AR USA 72205 Little Rock, AR 72205 USA
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
fascicolo: 1, volume: 280, anno: 2001,
pagine: F88 - F94
SICI:
0363-6127(200101)280:1<F88:CPAASO>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
CISPLATIN-INDUCED NEPHROTOXICITY; EXPERIMENTAL GLOMERULAR-DISEASE; SUPEROXIDE-DEPENDENT FORMATION; BLEOMYCIN-DETECTABLE IRON; PUROMYCIN AMINONUCLEOSIDE; REPERFUSION INJURY; HYDROXYL RADICALS; IN-VITRO; CELLS; TISSUE;
Keywords:
reactive oxygen metabolites; puromycin aminonucleoside; glomerular epithelial cells; cytochrome P-450 inhibitors;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Baliga, R Univ Mississippi, Med Ctr, Dept Pediat, Div Nephrol, 2500 N State St, Jackson, MS 39216 USA Univ Mississippi 2500 N State St Jackson MS USA39216 39216 USA
Citazione:
H. Liu et al., "Cytochrome P-450 as a source of catalytic iron in minimal change nephroticsyndrome in rats", AM J P-REN, 280(1), 2001, pp. F88-F94

Abstract

We have recently demonstrated an important pathogenic role for glomerular catalytic iron in the puromycin aminonucleoside (PAN) induced minimal change nephrotic syndrome (MCNS). The source of this iron capable of catalyzing free radical reactions is not known. We examined the role of cytochrome P-450 (CYP) as a source of catalytic iron in a model MCNS induced by single injection of PAN to rats. Treatment of PAN resulted in a marked increase in the catalytic iron associated with significant loss of glomerular CYP content. Administration of CYP inhibitors significantly prevented the injury-induced loss of CYP content and the increase in the catalytic iron in the glomeruli accompanied by a marked decrease in proteinuria. In an in vitro study utilizing glomerular epithelial cells (GEC), CYP inhibitors also markedly prevented the PAN-induced increase in the catalytic iron and hydroxyl radical formation accompanied by significant protection against PAN-induced cytotoxicity. Taken together our data indicate that the CYP, a group of heme protein, may serve as a significant source of this catalytic iron.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/05/20 alle ore 14:51:29