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Titolo:
Increased AT(1) receptor expression and mRNA in kidney glomeruli of AT(2) receptor gene-disrupted mice
Autore:
Saavedra, JM; Hauser, W; Ciuffo, G; Egidy, G; Hoe, KL; Johren, O; Sembonmatsu, T; Inagami, T; Armando, I;
Indirizzi:
NIMH, Pharmacol Sect, Bethesda, MD 20892 USA NIMH Bethesda MD USA 20892NIMH, Pharmacol Sect, Bethesda, MD 20892 USA Vanderbilt Univ, Sch Med, Dept Biochem, Nashville, TN 37232 USA VanderbiltUniv Nashville TN USA 37232 t Biochem, Nashville, TN 37232 USA
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
fascicolo: 1, volume: 280, anno: 2001,
pagine: F71 - F78
SICI:
0363-6127(200101)280:1<F71:IAREAM>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANGIOTENSIN-II RECEPTOR; SPONTANEOUSLY HYPERTENSIVE RATS; TISSUE-SPECIFIC EXPRESSION; IN-SITU HYBRIDIZATION; HUMAN RENAL-CORTEX; TYPE-2 RECEPTOR; QUANTITATIVE AUTORADIOGRAPHY; PRESSURE-NATRIURESIS; BLOOD-PRESSURE; CONSCIOUS RATS;
Keywords:
renin-angiotensin system; angiotensin II receptor types; gene-disrupted models;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Saavedra, JM NIMH, Pharmacol Sect, Dr MSC 1514,Bldg 10,Rm 2D-57, Bethesda,MD 20892 USA NIMH Dr MSC 1514,Bldg 10,Rm 2D-57 Bethesda MD USA 20892 2 USA
Citazione:
J.M. Saavedra et al., "Increased AT(1) receptor expression and mRNA in kidney glomeruli of AT(2) receptor gene-disrupted mice", AM J P-REN, 280(1), 2001, pp. F71-F78

Abstract

The proposed feedback between angiotensin II AT(2) and AT(1) receptors prompted us to study AT(1) receptor expression in kidneys of male AT(2) receptor-gene disrupted mice (agtr2 -/y). In wild-type (agtr2 +/y) mice, AT(1) receptor binding and mRNA is abundant in glomeruli, and AT(1) receptor binding is also high in the inner stripe of the outer medulla. AT(2) receptors are scarce, primarily associated to cortical vascular structures. In agtr2 -/y mice, AT(1) receptor binding and mRNA were increased in the kidney glomeruli, and AT(1) receptor binding was higher in the rest of the cortex and outer stripe of the outer medulla, but not in its inner stripe, indicating different cellular regulation. Although AT(2) receptor expression is very lowin male agtr2 +/y mice, their gene disruption alters AT(1) receptor expression. AT(1) upregulation alone may explain the AT(2) gene-disrupted mice phenotype such as increased blood pressure, higher sensitivity to angiotensinII, and altered renal function. The indirect AT(1)/AT(2) receptor feedbackcould have clinical significance because AT(1) antagonists are widely usedin medical practice.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 13:30:25