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Titolo:
Overexpression of tumor necrosis factor-alpha produces an increase in lungvolumes and pulmonary hypertension
Autore:
Fujita, M; Shannon, JM; Irvin, CG; Fagan, KA; Cool, C; Augustin, A; Mason, RJ;
Indirizzi:
Natl Jewish Med & Res Ctr, Dept Med, Denver, CO 80206 USA Natl Jewish Med & Res Ctr Denver CO USA 80206 t Med, Denver, CO 80206 USA Univ Colorado, Hlth Sci Ctr, Cardiovasc Pulm Res Lab, Denver, CO 80262 USAUniv Colorado Denver CO USA 80262 vasc Pulm Res Lab, Denver, CO 80262 USA
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
fascicolo: 1, volume: 280, anno: 2001,
pagine: L39 - L49
SICI:
1040-0605(200101)280:1<L39:OOTNFP>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
TNF-ALPHA; TRANSGENIC MICE; INDUCED EMPHYSEMA; FIBROSIS; EXPRESSION; MOUSE; INFLAMMATION; RECEPTOR; DISEASE; PROTEIN;
Keywords:
emphysema; pulmonary fibrosis; pulmonary hypertension;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Mason, RJ Natl Jewish Med & Res Ctr, Dept Med, 1400 Jackson St, Denver, CO80206 USA Natl Jewish Med & Res Ctr 1400 Jackson St Denver CO USA 80206 SA
Citazione:
M. Fujita et al., "Overexpression of tumor necrosis factor-alpha produces an increase in lungvolumes and pulmonary hypertension", AM J P-LUNG, 280(1), 2001, pp. L39-L49

Abstract

Tumor necrosis factor (TNF)-alpha is a key proinflammatory cytokine that is thought to be important in the development of pulmonary fibrosis, whereasits role in pulmonary emphysema has not been as thoroughly documented. In the present study, TNF-alpha was overexpressed in alveolar type II cells under the control of the human surfactant protein C promoter. In this report,we further characterized the pulmonary abnormalities and provided a physiological assessment of these mice. Histopathology of the lungs revealed chronic inflammation, severe alveolar air space enlargement and septal destruction, and bronchiolitis. However, pulmonary fibrosis was very limited and only seen in the subpleural, peribronchiolar, and perivascular regions. Physiological assessment showed an increase in lung volumes and a decrease in elastic recoil characteristic of emphysema; there was no evidence of restrictive lung disease characteristic of pulmonary fibrosis. In addition, the mice raised in ambient conditions in Denver developed pulmonary hypertension. Gelatinase activity was increased in the lavage fluid from these lungs. These results suggest that in these mice TNF-alpha contributed to the development of pulmonary emphysema through chronic lung inflammation and activationof the elastolytic enzymes but by itself was unable to produce significantpulmonary fibrosis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 13:18:05