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Titolo:
Fluconazole therapy in neonatal candidemia
Autore:
Huang, YC; Lin, TY; Lien, RI; Chou, YH; Kuo, CY; Yang, PH; Hsieh, WS;
Indirizzi:
Chang Gung Univ, Chang Gung Childrens Hosp, Div Pediat Infect Dis, Kweishan 333, Taoyuan, Taiwan Chang Gung Univ Kweishan Taoyuan Taiwan 333 Kweishan 333, Taoyuan, Taiwan
Titolo Testata:
AMERICAN JOURNAL OF PERINATOLOGY
fascicolo: 8, volume: 17, anno: 2000,
pagine: 411 - 415
SICI:
0735-1631(2000)17:8<411:FTINC>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTENSIVE-CARE UNIT; AMPHOTERICIN-B; RANDOMIZED TRIAL; CANDIDIASIS; FUNGEMIA; OUTBREAK;
Keywords:
fluconazole; neonate; candidemia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Huang, YC Chang Gung Univ, Chang Gung Childrens Hosp, Div Pediat Infect Dis, 5 Fu Shin St, Kweishan 333, Taoyuan, Taiwan Chang Gung Univ 5 Fu Shin StKweishan Taoyuan Taiwan 333 Taiwan
Citazione:
Y.C. Huang et al., "Fluconazole therapy in neonatal candidemia", AM J PERIN, 17(8), 2000, pp. 411-415

Abstract

We reviewed 62 episodes (from 59 infants) of neonatal candidemia that occurred between January 1994 and June 1999. Except 5 term babies, all infants were premature (median gestational age [GA], 30 weeks) and birth weight wasless than 2500 g (median, 1300 g). Most infants had reported risk factors and other neonatal problems. The age at onset of candidemia ranged from 15 to 173 days with a median of 34 days. In addition to catheter removal, all but one infants received antifungal agents and candidemia was eradicated subsequently in 46 episodes (75%). Eighteen infants with 19 episodes ever received fluconazole therapy. Fluconazole was administered as the first line agent in 6 episodes and successfully cleared candidemia in 5 episodes. Fluconazole was used as an alternative agent in an additional 13 episodes after amphotericin B (am B) +/- flucytosine were given for a period without a satisfactory result and eradication of candidemia was achieved in 8 episodes subsequently. All 18 infants tolerated fluconazole well and no withdrawal was required on account of its adverse effect. In contrast, am B alone was administered as the first line agent in 55 episodes and successfully cleared candidemia in 32 episodes (58%). This retrospective analysis suggests that fluconazole appears to be safe in neonates and can be used as an alternative agent in treating neonatal candidemia. A large-scaled prospective study may be needed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 10:49:39