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Titolo:
Alzheimer's disease: Clinical treatment options
Autore:
Reichman, WE;
Titolo Testata:
AMERICAN JOURNAL OF MANAGED CARE
fascicolo: 22, volume: 6, anno: 2000, supplemento:, S
pagine: S1125 - S1138
SICI:
1088-0224(200012)6:22<S1125:ADCTO>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
DOUBLE-BLIND; CONTROLLED TRIAL; DEMENTIA; PLACEBO; ABNORMALITIES; DYSFUNCTION; FLUVOXAMINE; CITALOPRAM; SERTRALINE; DONEPEZIL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
W.E. Reichman, "Alzheimer's disease: Clinical treatment options", AM J M CARE, 6(22), 2000, pp. S1125-S1138

Abstract

Comprehensive treatment of Alzheimer's disease (AD) requires thorough caregiver support and a thoughtful and informed use of medications for cognition enhancement, neuroprotection, and the treatment of disturbed behavior. Current treatments such as the cholinesterase inhibitors donepezil and rivastigmine can slow the progression of cognitive and functional deficits in AD over the short term. Sustained improvement and possible disease modification that result from the use of these medications are being evaluated in long-term studies. Treatment with alpha-tocopherol (vitamin E) has been shown to delay the progression of nursing home admission in patients with mild-to-moderate AD. Although antioxidant, anti-inflammatory, and other treatment strategies are promising, recent studies of the treatment of AD with estrogen or prednisone have produced disappointing results. For managing the behavioral symptoms that commonly accompany AD (eg, delusions, aggression, depression, anxiety, irritability), various antipsychotics, antidepressants, andanticonvulsants have been effective in carefully selected patients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 02:40:05