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Titolo:
The coffee diterpene cafestol increases plasma triacylglycerol by increasing the production rate of large VLDL apolipoprotein B in healthy normolipidemic subjects
Autore:
de Roos, B; Caslake, MJ; Stalenhoef, AFH; Bedford, D; Demacker, PNM; Katan, MB; Packard, CJ;
Indirizzi:
Univ Wageningen & Res Ctr, Div Human Nutr & Epidemiol, NL-6703 HA Wageningen, Netherlands Univ Wageningen & Res Ctr Wageningen Netherlands NL-6703 HA Netherlands Glasgow Royal Infirm, Dept Pathol Biochem, Glasgow G4 0SF, Lanark, Scotland Glasgow Royal Infirm Glasgow Lanark Scotland G4 0SF 0SF, Lanark, Scotland Univ Nijmegen Hosp, Div Internal Med, NL-6500 HB Nijmegen, Netherlands Univ Nijmegen Hosp Nijmegen Netherlands NL-6500 HB Nijmegen, Netherlands
Titolo Testata:
AMERICAN JOURNAL OF CLINICAL NUTRITION
fascicolo: 1, volume: 73, anno: 2001,
pagine: 45 - 52
SICI:
0002-9165(200101)73:1<45:TCDCIP>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHOLESTEROL-RAISING FACTOR; CORONARY HEART-DISEASE; TRIGLYCERIDE TRANSFER PROTEIN; DENSITY-LIPOPROTEIN CHOLESTEROL; BOILED COFFEE; LIVER AMINOTRANSFERASES; PRECIPITATION METHOD; SERUM-CHOLESTEROL; HEPG2 CELLS; OLEIC-ACID;
Keywords:
healthy men; cafestol; VLDL1 apolipoprotein B; catabolism; VLDL composition; unfiltered coffee; cafetiere coffee; French-press coffee; triacylglycerol; triglyceride;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Katan, MB Univ Wageningen & Res Ctr, Div Human Nutr & Epidemiol, Bomenweg 2, NL-6703HA Wageningen, Netherlands Univ Wageningen & Res Ctr Bomenweg 2 Wageningen Netherlands NL-6703 HA
Citazione:
B. de Roos et al., "The coffee diterpene cafestol increases plasma triacylglycerol by increasing the production rate of large VLDL apolipoprotein B in healthy normolipidemic subjects", AM J CLIN N, 73(1), 2001, pp. 45-52

Abstract

Background: Cafestol is a diterpene in unfiltered coffee that raises plasma triacylglycerol in humans. Objective: We studied whether cafestol increases plasma triacylglycerol byincreasing the production rate or by decreasing the fractional catabolic rate of VLDL1 [Svedberg flotation unit (S-f) 60-400] apolipoprotein(apo) B. In addition, we studied the effect of cafestol on the composition of VLDL1 and VLDL2 (S-f 20-60). Design: Eight healthy normolipidemic men were administered a daily dose of75 mg cafestol for 2 wk. A bolus injection of 7 mg L-[5,5,5-H-2(3)]leucine/kg body wt was given after a baseline period with no cafestol and again after treatment with cafestol. We derived kinetic constants to describe the metabolism of VLDL1 apo B by using a multicompartmental model. Results: Cafestol significantly increased plasma triacylglycerol by 31% or0.32 mmol/L (95% CI: 0.03, 0.61); the increase was due mainly to a nonsignificant rise in VLDL1 triacylglycerol of 57% or 0.23 mmol/L (95% CI: -0.02,0.48). Cafestol significantly increased the mean rate of VLDL1 apo B production by 80% or 755 mg/d (95% CI: 0.2, 5353), whereas it did not significantly change the mean fractional catabolic rate of VLDL1 apo B (mean increaseof 3 pools/d; 95% CI: -4, 10]). Cafestol did not change the composition ofVLDL1. A significant increase in the ratio of VLDL2 cholesteryl ester to triacylglycerol indicates that VLDL2 became enriched with cholesteryl estersat the cost of triacylglycerol. Conclusion: Cafestol increases plasma triacylglycerol by increasing the production rate of VLDL1 apo B, probably via increased assembly of VLDL1 in the liver.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 09:44:56