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Titolo:
The neurotrophin hypothesis for synaptic plasticity
Autore:
Schinder, AF; Poo, MM;
Indirizzi:
Univ Calif San Diego, Dept Biol, La Jolla, CA 92093 USA Univ Calif San Diego La Jolla CA USA 92093 t Biol, La Jolla, CA 92093 USA
Titolo Testata:
TRENDS IN NEUROSCIENCES
fascicolo: 12, volume: 23, anno: 2000,
pagine: 639 - 645
SICI:
0166-2236(200012)23:12<639:TNHFSP>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM POTENTIATION; NERVE GROWTH-FACTOR; RAT VISUAL-CORTEX; CULTURED HIPPOCAMPAL-NEURONS; BDNF KNOCKOUT MICE; ANTEROGRADE TRANSPORT; MESSENGER-RNA; ADULT HIPPOCAMPUS; DENDRITIC GROWTH; TRKB RECEPTOR;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
79
Recensione:
Indirizzi per estratti:
Indirizzo: Schinder, AF Univ Calif San Diego, Dept Biol, La Jolla, CA 92093 USA Univ Calif San Diego La Jolla CA USA 92093 lla, CA 92093 USA
Citazione:
A.F. Schinder e M.M. Poo, "The neurotrophin hypothesis for synaptic plasticity", TRENDS NEUR, 23(12), 2000, pp. 639-645

Abstract

The neurotrophin hypothesis proposes that neurotrophins participate in activity-induced modification of synaptic transmission. Increasingly, evidenceindicates that the synthesis, secretion and actions of neurotrophins on synaptic transmission are regulated by electrical activity and that neurotrophins themselves can acutely modify synaptic efficacy Neurotrophins appear to exert either a permissive or instructive role on activity-dependent synaptic potentiation and depression, which depends on the particular synaptic connections and developmental stages. The characteristics of synaptic changes that are induced by neurotrophins suggest that this family of proteins iscrucial for providing a molecular background in which activity-dependent plasticity can occur at selective synaptic sites within the neural network.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 05:15:28