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Titolo:
Chikungunya fever as a risk factor for endemic Burkitt's lymphoma in Malawi
Autore:
van den Bosch, C; Lloyd, G;
Indirizzi:
Hammersmith Hosp, Royal Postgrad Med Sch, Dept Virol, London W12 0NN, England Hammersmith Hosp London England W12 0NN t Virol, London W12 0NN, England Kamuzu Cent Hosp, Lilongwe, Malawi Kamuzu Cent Hosp Lilongwe MalawiKamuzu Cent Hosp, Lilongwe, Malawi Publ Hlth Lab Serv, Ctr Appl Microbiol & Res, Salisbury SP4 0JG, Wilts, England Publ Hlth Lab Serv Salisbury Wilts England SP4 0JG P4 0JG, Wilts, England
Titolo Testata:
TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE
fascicolo: 6, volume: 94, anno: 2000,
pagine: 704 - 705
SICI:
0035-9203(200011/12)94:6<704:CFAARF>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Keywords:
chikungunya fever; seroprevalence; time-space case-clusters; arbovirus; Burkitt's lymphoma; Malawi;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
7
Recensione:
Indirizzi per estratti:
Indirizzo: van den Bosch, C Dept Publ Hlth, E London, England Dept Publ Hlth E London England lth, E London, England
Citazione:
C. van den Bosch e G. Lloyd, "Chikungunya fever as a risk factor for endemic Burkitt's lymphoma in Malawi", T RS TROP M, 94(6), 2000, pp. 704-705

Abstract

The geographical and age distributions of endemic Burkitt's lymphoma (eBL), in Africa, parallel those of certain arboviruses, which include chikungunya fever. Increased incidences of antibodies to assorted arboviruses, including chikungunya, have been found in eBL sera compared to controls. An increased incidence and space-time case-clusters of eBL occurred during a chikungunya fever epidemic which were confirmed by serology and clinical observation. The present study, conducted in 1987-89, involved 108 eBL patients, and 97 local and 111 hospital controls. We examined, as hospital controls, patients with afebrile, non-malignant conditions admitted to Kamuzu Central Hospital, Malawi, during the eBL patients' first admission there. Analyses were for hospital controls and eBL patients at the end of their first admission and for local controls and eBL patients at the beginning of their third admission, about 8 weeks after the day of first admission, because of thelocal controls' temporal bias. Patients in case-clusters were among those seropositive for chikungunya virus, with a history compatible with arbovirus infection preceding the lymphoma, suggesting involvement of chikungunya virus in the case-clusters and a possible association between recent infection with this virus and development of the lymphoma. eBL patients were significantly more likely to be seropositive for chikungunya virus antibody (68.5%) than either hospital controls (46.8%) or local controls (50.5%) (P = 0.002 and 0.009, respectively), raising the possibility of an association between infection with an arbovirus and developing eBL in children already primed by holoendemic malaria and Epstein-Barr virus infection.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 10:26:46