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Titolo:
Influence of amino acids on okadaic acid production
Autore:
Souto, ML; Fernandez, DJ; Norte, M; Fernandez, ML; Martinez, A;
Indirizzi:
Univ La Laguna, Inst Univ Bioorgan Antonio Gonzalez, E-38206 Tenerife, Spain Univ La Laguna Tenerife Spain E-38206 Gonzalez, E-38206 Tenerife, Spain European Community Reference Lab, Sanidad Exterior, Vigo 36271, Spain European Community Reference Lab Vigo Spain 36271 ior, Vigo 36271, Spain
Titolo Testata:
TOXICON
fascicolo: 5, volume: 39, anno: 2001,
pagine: 659 - 664
SICI:
0041-0101(200105)39:5<659:IOAAOO>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
DIARRHETIC SHELLFISH TOXINS; BIOSYNTHETIC ORIGIN; PROROCENTRUM-LIMA; DINOPHYSISTOXIN-1; PHOSPHATASES; DERIVATIVES; ESTER;
Keywords:
okadaic acid; Diarrhetic Shellfish Poisoning; polyether toxins;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Fernandez, DJ Univ La Laguna, Inst Univ Bioorgan Antonio Gonzalez, Astrofis Francisco Sanchez 2, E-38206 Tenerife, Spain Univ La Laguna Astrofis Francisco Sanchez 2 Tenerife Spain E-38206
Citazione:
M.L. Souto et al., "Influence of amino acids on okadaic acid production", TOXICON, 39(5), 2001, pp. 659-664

Abstract

Okadaic acid (OA) (1) was the first example of a group of polyether toxinsknown to be produced by marine microalgae, which are responsible for the natural phenomena known as Diarrhetic Shellfish Poisoning (DSP) red tides. It is also a highly selective inhibitor of protein phosphatases type 1 (PP1)and 2A (PP2A), as well as being a potent tumour promoter. For these reasons, OA is an extremely useful tool for studying cellular processes and an important standard for polluted shellfish control. In this paper. we report on a double objective: to improve the production of toxins and verify the apparent participation of amino acids in the formation of these polyethers bymonitoring their influence on the promotion of growth, total cell yield and increased in toxicity in Prorocentrum lima of the PL2V strain in batch cultures, in a modified K medium. (C) 2000 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 19:16:20