Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
ANTIFILARIAL ACTIVITY OF A SYNTHETIC MARINE ALKALOID, APLYSINOPSIN (CDRI-COMPOUND-92 138)/
Autore:
SINGH SN; BHATNAGAR S; FATMA N; CHAUHAN PMS; CHATTERJEE RK;
Indirizzi:
CENT DRUG RES INST,DIV PARASITOL LUCKNOW 226001 UTTAR PRADESH INDIA CENT DRUG RES INST,DIV PARASITOL LUCKNOW 226001 UTTAR PRADESH INDIA CENT DRUG RES INST,DIV MED CHEM LUCKNOW 226001 UTTAR PRADESH INDIA
Titolo Testata:
TM & IH. Tropical medicine & international health
fascicolo: 6, volume: 2, anno: 1997,
pagine: 535 - 543
SICI:
1360-2276(1997)2:6<535:AAOASM>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
HIGH-DOSE IVERMECTIN; BANCROFTIAN FILARIASIS; LYMPHATIC FILARIASIS; EXPERIMENTAL CHEMOTHERAPY; BIOLOGICAL-ACTIVITIES; DIETHYLCARBAMAZINE; INFECTION; EFFICACY; STRATEGIES; RECIFE;
Keywords:
APLYSINOPSIN; ANTIFILARIAL; L-CARINII; A-VITEAE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
S.N. Singh et al., "ANTIFILARIAL ACTIVITY OF A SYNTHETIC MARINE ALKALOID, APLYSINOPSIN (CDRI-COMPOUND-92 138)/", TM & IH. Tropical medicine & international health, 2(6), 1997, pp. 535-543

Abstract

CDRI Compound 92/138, a synthetic analogue of aplysinopsin, was evaluated in experimental filarial infections, Litomosoides carinii in cotton rats (Sigmodon hispidus) and Acanthocheilonema viteae in Mastomys coucha. The compound killed 63.8 and 90% of adult L. carinii and A. viteae at doses of 30 and 50 mg/kg (i.p.) respectively given for 5 days. By the oral route, at 100 mg/kg for 5 days the compound caused 50.9 and 57% mortality of adult L. carinii and A. viteae, respectively. At 200 mg/kg administered orally on days 0, 10 and 25 post-infection, it reduced establishment of adult A. viteae by 68.5%. We also found 43.7 and 37.8% effect in vivo respectively on L-3 and L-4 stages of A. viteaeat a single dose of 250 mg/kg, p.o. The compound was active in vitro at 100 mu g/ml concentration and caused a significant decline in MTT reduction and C-14-glucose uptake by adult filariids. Thus synthetic marine aplysinopsin could provide a new pharmacophore for the development of antifilarial agents.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 13:54:54