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Titolo:
Hepatic disposition of neurotoxins and pesticides
Autore:
Yang, MC; McLean, AJ; Rivory, LP; Le Couteur, DG;
Indirizzi:
Univ Sydney, Dept Clin Pharmacol, Canberra Hosp, Canberra Clin Sch, Garran, ACT 2605, Australia Univ Sydney Garran ACT Australia 2605 in Sch, Garran, ACT 2605, Australia Royal Prince Alfred Hosp, Sydney Canc Ctr, Camperdown, NSW, Australia Royal Prince Alfred Hosp Camperdown NSW Australia erdown, NSW, Australia
Titolo Testata:
PHARMACOLOGY & TOXICOLOGY
fascicolo: 6, volume: 87, anno: 2000,
pagine: 286 - 291
SICI:
0901-9928(200012)87:6<286:HDONAP>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
MULTIPLE-INDICATOR DILUTION; ORGANIC CATION TRANSPORTER; ENVIRONMENTAL RISK-FACTORS; PERFUSED-RAT-LIVER; PARKINSONS-DISEASE; OXIDATIVE INJURY; GLUCOSE-TRANSPORT; PARAQUAT; MPTP; 1-METHYL-4-PHENYLPYRIDINIUM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Yang, MC Univ Sydney, Dept Clin Pharmacol, Canberra Hosp, Canberra Clin Sch, Yamba Dr, Garran, ACT 2605, Australia Univ Sydney Yamba Dr Garran ACT Australia 2605 CT 2605, Australia
Citazione:
M.C. Yang et al., "Hepatic disposition of neurotoxins and pesticides", PHARM TOX, 87(6), 2000, pp. 286-291

Abstract

The hepatic disposition of pesticides and neurotoxins may influence susceptibility to Parkinson's disease. Therefore we examined the behaviour of paraquat, dichlorodiphenyltrichloroethane (DDT), malathion and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in perfused rat liver using the multiple indicator-dilution technique. The values for the recovery of paraquat, DDT, malathion and MPTP were 1.05+/-0.12, 0.32+/-0.01, 0.11+/-0.02. and 0.02/-0.01, respectively. The volumes of distribution were 0.28+/-0.13, 0.69+/-0.12, 3.30+/-0.58 and 5.10+/-6.00 ml/g, respectively The permeability-surface area products suggest that transport of DDT and MPTP across cell membranes is by simple diffusion. However, there may be a specific influx mechanism for malathion and a specific efflux mechanism for paraquat. There is considerable variability in the hepatic disposition of putative neurotoxins such as MPTP and pesticides. Factors that influence the hepatic disposition of neurotoxins may alter susceptibility to neurotoxic diseases however the effects will be diverse.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 22:48:34