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Titolo:
Comparative genomic hybridization analysis suggests a gain of chromosome 7p associated with lymph node metastasis in non-small cell lung cancer
Autore:
Ubagai, T; Matsuura, S; Tauchi, H; Itou, K; Komatsu, K;
Indirizzi:
Hiroshima Univ, Res Inst Radiat Biol & Med, Dept Radiat Biol, Minami Ku, Hiroshima 7348553, Japan Hiroshima Univ Hiroshima Japan 7348553 nami Ku, Hiroshima 7348553, Japan Hiroshima Univ, Sch Med, Dept Radiol, Minami Ku, Hiroshima 7348553, Japan Hiroshima Univ Hiroshima Japan 7348553 nami Ku, Hiroshima 7348553, Japan
Titolo Testata:
ONCOLOGY REPORTS
fascicolo: 1, volume: 8, anno: 2001,
pagine: 83 - 88
SICI:
1021-335X(200101/02)8:1<83:CGHASA>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
OVARIAN-CANCER; CARCINOMA; ADENOCARCINOMA; HETEROZYGOSITY; FREQUENT; GENE; IDENTIFICATION; ALLELOTYPE; INVASION; ONCOGENE;
Keywords:
comparative genomic hybridization; non-small cell lung cancer; lymph node metastasis; metastasis-associated gene; gain of chromosome 7p;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Komatsu, K Hiroshima Univ, Res Inst Radiat Biol & Med, Dept Radiat Biol, Minami Ku, Kasumi 1-2-3, Hiroshima 7348553, Japan Hiroshima Univ Kasumi 1-2-3 Hiroshima Japan 7348553 553, Japan
Citazione:
T. Ubagai et al., "Comparative genomic hybridization analysis suggests a gain of chromosome 7p associated with lymph node metastasis in non-small cell lung cancer", ONCOL REP, 8(1), 2001, pp. 83-88

Abstract

We analyzed the chromosomal gains and losses that occur in 30 non-small cell lung carcinomas by comparative genomic hybridization. Their chromosomal imbalances showed histological type-specific patterns in adenocarcinomas and in squamous cell carcinomas. The genetic changes in non-small cell lung carcinoma were also strongly dependent on metastasis to lymph node. The average numbers of chromosomal alterations were increased from 6.2 to 9.1 alongwith the presence of metastasis, and it gave rise to the increased copy number in specific chromosomes. In particular, a novel imbalance at 7p12-21 was recognized in a half of carcinoma with metastasis, although no genetic alteration was observed in 15 non-metastasizing lung carcinoma tested here.

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Documento generato il 31/03/20 alle ore 18:53:07