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Titolo:
Different characteristics of carcinoma in the gastric remnant: Histochemical and immunohistochemical studies
Autore:
Matsui, N; Yao, T; Akazawa, K; Nawata, H; Tsuneyoshi, M;
Indirizzi:
Kyushu Univ, Grad Sch Med Sci, Dept Anat Pathol, Higashi Ku, Fukuoka 8128582, Japan Kyushu Univ Fukuoka Japan 8128582 ol, Higashi Ku, Fukuoka 8128582, Japan Kyushu Univ, Grad Sch Med Sci, Dept Med Informat, Fukuoka 8128582, Japan Kyushu Univ Fukuoka Japan 8128582 t Med Informat, Fukuoka 8128582, Japan Kyushu Univ, Grad Sch Med Sci, Dept Med & Bioregulatory Sci, Fukuoka 8128582, Japan Kyushu Univ Fukuoka Japan 8128582 regulatory Sci, Fukuoka 8128582, Japan
Titolo Testata:
ONCOLOGY REPORTS
fascicolo: 1, volume: 8, anno: 2001,
pagine: 17 - 26
SICI:
1021-335X(200101/02)8:1<17:DCOCIT>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTESTINAL METAPLASIA; STUMP CANCER; DUODENOGASTRIC REFLUX; PARTIAL GASTRECTOMY; STOMACH; EXPRESSION; P53; MUCOSA; RISK; ADENOCARCINOMAS;
Keywords:
carcinoma; gastric remnant; mucin histochemistry; immunohistochemistry; p53;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
53
Recensione:
Indirizzi per estratti:
Indirizzo: Tsuneyoshi, M Kyushu Univ, Grad Sch Med Sci, Dept Anat Pathol, Higashi Ku,3-1-1 Maidashi, Fukuoka 8128582, Japan Kyushu Univ 3-1-1 Maidashi FukuokaJapan 8128582 582, Japan
Citazione:
N. Matsui et al., "Different characteristics of carcinoma in the gastric remnant: Histochemical and immunohistochemical studies", ONCOL REP, 8(1), 2001, pp. 17-26

Abstract

Seventy cases of cancer of the gastric remnant were divided into three groups: 33 cases following surgery for benign disease (group A), and 15 cases occurring more than 10 years and 22 cases occurring within 10 years after the first gastrectomy for malignant disease (groups B and C, respectively). Then mucin histochemical and immunohistochemical studies were undertaken. Billroth-II procedure for anastomosis was most frequently performed in groupA. Intestinal metaplasia within the mucosa surrounding the carcinomas was more frequently present in groups A and C with a diffuse distribution. Intestinal-type surrounding mucosa was significantly more frequent in group C. The immunohistochemical expression of p53 protein was most frequently expressed in group B. We conclude that a different mechanism of carcinogenesis exists in these three groups; i) Group A: the reflux of duodenal juice especially following B-II procedures leads to progression of the carcinoma. ii) Group B: some genetic factor such as p53 may be related to the metachronousmultiple carcinogenesis. iii) Group C: metachronous multiple carcinogenesis within the short interval may be closely associated with diffuse intestinal metaplasia in the surrounding mucosa.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/10/20 alle ore 01:34:41