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Titolo:
Mutation analysis of the N-methyl-D-aspartate receptor NR1 subunit gene (GRIN1) in schizophrenia
Autore:
Sakurai, K; Toru, M; Yamakawa-Kobayashi, K; Arinami, T;
Indirizzi:
Univ Tsukuba, Inst Basic Med Sci, Dept Med Genet, Tsukuba, Ibaraki 3058575, Japan Univ Tsukuba Tsukuba Ibaraki Japan 3058575 sukuba, Ibaraki 3058575, Japan Tokyo Med & Dent Univ, Sch Med, Dept Neuropsychiat, Tokyo 113, Japan TokyoMed & Dent Univ Tokyo Japan 113 pt Neuropsychiat, Tokyo 113, Japan
Titolo Testata:
NEUROSCIENCE LETTERS
fascicolo: 2-3, volume: 296, anno: 2000,
pagine: 168 - 170
SICI:
0304-3940(200012)296:2-3<168:MAOTNR>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
TARGETED DISRUPTION; MICE LACKING; PHENCYCLIDINE; IMPAIRMENT; KETAMINE; CHANNEL; NMDAR1; MODEL;
Keywords:
N-methyl-D-aspartate receptor NR1 subunit gene; schizophrenia; association; mutation; genome;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Arinami, T Univ Tsukuba, Inst Basic Med Sci, Dept Med Genet, Tsukuba, Ibaraki 3058575, Japan Univ Tsukuba Tsukuba Ibaraki Japan 3058575 raki 3058575, Japan
Citazione:
K. Sakurai et al., "Mutation analysis of the N-methyl-D-aspartate receptor NR1 subunit gene (GRIN1) in schizophrenia", NEUROSCI L, 296(2-3), 2000, pp. 168-170

Abstract

Dysfunction of N-methyl-D-aspartate (NMDA) type ionotropic glutamate receptors has been implicated in the etiology of schizophrenia based on psychotomimetic properties of the antagonist phencyclidine (PCP) and observation that mice expressing low revels of the N-methyl-D-aspartate receptor NR1 subunit exhibit behavioral alterations that may be ameliorated by neuroleptic drugs. Based on the hypothesis that some schizophrenic patients have functionally deficient mutation(s) of the gene encoding N-methyl-D-aspartate receptor NR1 subunit (GRIN1), we screened 48 Japanese patients with schizophrenia for mutations in the coding region of the GRIN1 gene. Four variants, IVS2-22T > C, IVS2-12G > A, IVS4-34C > T, and 1719G/A (Pro516Pro), were identified. No non-synonymous mutation was detected. No significant association was suggested by case-control comparisons. Results indicate that genomic variations of the GRIN1 gene are not likely to be involved substantially in theetiology of schizophrenia. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 10:54:14