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Titolo:
Acamprosate reduces motor cortex excitability determined by transcranial magnetic stimulation
Autore:
Wohlfarth, K; Schneider, U; Haacker, T; Schubert, M; Schulze-Bonhage, A; Zedler, M; Emrich, HM; Dengler, R; Rollnik, JD;
Indirizzi:
Hannover Med Sch, Dept Neurol & Clin Neurophysiol, D-30623 Hannover, Germany Hannover Med Sch Hannover Germany D-30623 iol, D-30623 Hannover, Germany Hannover Med Sch, Dept Clin Psychiat & Psychotherapy, D-30623 Hannover, Germany Hannover Med Sch Hannover Germany D-30623 apy, D-30623 Hannover, Germany Univ Bonn, Dept Epileptol, D-5300 Bonn, Germany Univ Bonn Bonn Germany D-5300 Bonn, Dept Epileptol, D-5300 Bonn, Germany
Titolo Testata:
NEUROPSYCHOBIOLOGY
fascicolo: 4, volume: 42, anno: 2000,
pagine: 183 - 186
SICI:
0302-282X(2000)42:4<183:ARMCED>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORTICAL EXCITABILITY; BRAIN-STIMULATION; INHIBITION; HOMOTAURINE; RECEPTORS; RESPONSES; UNITS; RATS;
Keywords:
acamprosate; motor cortex; excitability; transcranial magnetic stimulation; motor evoked potentials;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Rollnik, JD Hannover Med Sch, Dept Neurol, D-30623 Hannover, Germany Hannover Med Sch Hannover Germany D-30623 Hannover, Germany
Citazione:
K. Wohlfarth et al., "Acamprosate reduces motor cortex excitability determined by transcranial magnetic stimulation", NEUROPSYCHB, 42(4), 2000, pp. 183-186

Abstract

Acamprosate is effective in reducing alcohol intake in weaned alcoholics, We were interested if acamprosate had an effect on the excitability of cortical motoneurons determined by transcranial magnetic stimulation (TMS), We studied 12 male healthy volunteers (mean age 29.5 years, SD = 4.8) who wereeither treated with 6 tablets of acamprosate (each containing 333 mg verum) per day or placebo (randomized cross-over design) for 1 week. TMS was performed after each treatment session including a paired stimulation paradigm. Motor evoked potentials (MEPs) of the placebo and verum group did not differ with respect to paired stimulation, However, motor threshold increased in the acamprosate group (verum: 61.5% (SD = 7.9) vs. placebo: 58.9% (SD = 8.8), p = 0.036), We conclude that acamprosate leads to a hypoexcitability of the motor cortex. This might be due to subcortical mechanisms, e.g. thalamocortical pathways since intracortical inhibition and facilitation was not affected. Copyright (C) 2000 S. Karger AG, Basel.

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Documento generato il 29/03/20 alle ore 18:22:04